Now showing items 1-20 of 13384
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1,3,4-Oxadiazol-2-ylbenzenesulfonamides as privileged structures for the inhibition of monoamine oxidase B
(Elsevier, 2019)The present study investigates the monoamine oxidase (MAO) inhibition properties of a series of ten 5-aryl-1,3,4-oxadiazol-2-ylbenzenesulfonamides. The target compounds were synthesized by dehydration of the corresponding ... -
1,3,7-Triethyl-substituted xanthines-possess nanomolar affinity for the adenosine A1 receptor
(Elsevier, 2015)Adenosine A1 receptors are attracting great interest as drug targets for their role in cognitive deficits. Antagonism of the adenosine A1 receptor may offer therapeutic benefits in complex neurological diseases, such as ... -
1-Bromo-2-(10 β-dihydroartemisinoxy)-ethane
(IUCr, 2010)The title compound, C17H27BrO5, DEB, is a derivative of artemisinin which is used in malaria therapy. The OR-group at C12 is cis to the CH3-group at C11 and axially oriented on ring D which has a chair conformation. The ... -
A 10-year follow-up study of demographic and cardiometabolic factors in HIV-infected South Africans
(Clinics Cardive Publishing, 2019)Objectives: Understanding of the interplay between human immunodeficiency virus (HIV) and cardiovascular disease, especially in Africa, is limited to evidence from longitudinal studies. Therefore the demographic profile ... -
100 Years of atmospheric and marine observations at the Finnish Utö Island in the Baltic Sea
(EGU, 2018)The Utö Atmospheric and Marine Research Station introduced in this paper is located on Utö Island (59°46.84′N, 21°22.13′E) at the outer edge of the Archipelago Sea, by the Baltic Sea towards the Baltic Proper. Meteorological ... -
11-Azaartemisinin cocrystals with preserved lactam : acid heterosynthons
(RSC, 2018)11-Azaartemisinin (11-Aza) is a potent anti-malarial drug more readily able to form cocrystals than its parent compound. 13 new 1 : 1 and 2 : 1 cocrystal phases from 25 mono- and bi-functional acids are reported here in ... -
13CH3OH masers associated with a transient phenomenon in a high-mass young stellar object
(IOP, 2020)We report the first detection of isotopic methanol (13CH3OH) maser emission in interstellar space. The emission was detected toward the high-mass young stellar object G358.93-0.03 during monitoring of a flare in the 6.7 ... -
The 1960s - long hair, flowers and morality mash: Ethical appraisal of the clash that helped shape today's Western society
(Gereformeerde Teologiese Vereniging, 2009)The 1960s will be remembered as a major clash that helped shape today's Western society. Young people were breaking out of the moulds that had been cast by their parents' post-war era. The conflict brought about significant ... -
1994: new academic profession for a new South Africa?
(Taylor and Francis, 2015)Since 1994, the eyes of the world have been on South Africa, observing with interest the societal reconstruction project, upon which the country had embarked. In this project, higher education is both the terrain and the ... -
1H NMR spectral identification of medication in cerebrospinal fluid of pediatric meningitis
(Elsevier, 2017)Exploratory metabolomics studies of cerebrospinal fluid (CSF), using proton nuclear magnetic resonance (1H NMR) spectroscopy, hold major potential application in neurodiagnostics. Such studies, however, rely upon established ... -
The 1H-NMR-based metabolite profile of acute alcohol consumption: a metabolomics intervention study
(PLoS, 2018)Metabolomics studies of disease conditions related to chronic alcohol consumption provide compelling evidence of several perturbed metabolic pathways underlying the pathophysiology of alcoholism. The objective of the present ... -
2, 10-dimethylacridin-9(10H)-one as New Synthesized Corrosion Inhibitor for C38 Steel in 0.5 M H2SO4
(ESG, 2015)The corrosion inhibition of C38 steel in 0.5 M H2SO4 solution by 2,10-dimethylacridin-9(10H)-one (DMA) has been studied using electrochemical polarization , electrochemical impedance spectroscopy (EIS) and weight loss ... -
2,4-Diamino-5-(phenylthio)-5H-chromeno [2,3-b] pyridine-3-carbonitriles as green and effective corrosion inhibitors: gravimetric, electrochemical, surface morphology and theoretical studies
(Royal Society of Chemistry, 2016)The inhibition of mild steel corrosion in 1 M HCl by three newly synthesized 2,4-diamino-5-(phenylthio)-5H-chromeno[2,3-b]pyridine-3-carbonitriles (DHPCs) namely, 2,4-diamino-7-nitro-5-(phenylthio)-5H-chromeno[2,3-b]pyri ... -
2-Acetylphenol analogs as potent reversible monoamine oxidase inhibitors
(Dove Press, 2015)Based on a previous report that substituted 2-acetylphenols may be promising leads for the design of novel monoamine oxidase (MAO) inhibitors, a series of C5-substituted 2-acetylphenol analogs (15) and related compounds ... -
2-Aminopyrimidines as dual adenosine A1/A2A antagonists
(Elsevier, 2015)In this study thirteen 2-aminopyrimidine derivatives were synthesised and screened as potential antagonists of adenosine A1 and A2A receptors in order to further investigate the structure activity relationships of this ... -
2-Benzylidene-1-indanone analogues as dual adenosine A1/A2a receptor antagonists for the potential treatment of neurological conditions
(Thieme, 2019)Previous studies explored 2-benzylidine-1-tetralone derivatives as innovative adenosine A1 and A2A receptor antagonists for alternative non-dopaminergic treatment of Parkinson’s disease. This study’s aim is to investigate ... -
2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2016)In the present study, a series of twenty-two 2-benzylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 2-benzylidene-1-indanone derivatives ... -
A 2-Decade Appraisal of African Nursing Scholarship: 1986-2006
(Wiley-Blackwell, 2009)This paper is a description of a study about articles published about nursing in Africa from 1986 to 2006. METHODS: An exhaustive database search of articles written by nurses or articles related to nursing in Africa was ... -
(2-Ethyl-2-oxazoline- kN)bis(N-ethyl-N-phenyldithiocarbamato- k2S,S')cadmium
(International Union of Crystallography, 2012)In the title compound, [Cd(C9H10NS2)2(C5H9NO)], the CdII atom is five-coordinated in a distorted square-pyramidal geometry by four S atoms from two chelating N-ethyl-N- phenyl dithiocarbamate ligands and one N atom from a ... -
2-Heteroarylidene-1-indanone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2016)In the present study a series of fifteen 2-heteroarylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. These compounds are structurally related ...
