Now showing items 1-3 of 3

    • Combining chemical permeation enhancers for synergistic effects 

      Du Toit, Trizel; Malan, Maides M.; Lemmer, Hendrik J.R.; Gouws, Chrisna; Aucamp, Marique E.; Breytenbach, Wilma J.; Hamman, Josias H. (Springer, 2016)
      Currently, macromolecular drugs such as proteins are mainly administered by means of injections due to their low intestinal epithelial permeability and poor stability in the gastrointestinal tract. This study ...
    • Excipients with specialized functions for effective drug delivery 

      Hamman, Josias; Steenekamp, Jan (Taylor & Francis, 2012)
      Introduction: There is a growing need for the development of pharmaceutical excipients that could improve product performance and overcome the shortcomings of new drug moieties, such as their poor solubility and membrane ...
    • Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride 

      Du Plessis, Lissinda H.; Kotzé, Awie F.; Junginger, Hans E. (Taylor & Francis, 2010)
      The aim of this study was to evaluate the ability of TMC, with different degrees of quaternization, to increase insulin absorption in vivo following nasal and rectal administration in rats. Two batches of TMC with different ...