Browsing Research Output by Subject "α-Synuclein"
Now showing items 1-2 of 2
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Advances in GBA-associated Parkinson's disease: pathology, presentation and therapies
(Elsevier, 2016)GBA mutations are to date the most common genetic risk factor for Parkinson's disease. The GBA gene encodes the lysomal hydrolase glucocerebrosidase. Whilst bi-allelic GBA mutations cause Gaucher disease, both mono- and ... -
Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats
(Springer, 2016)We previously reported a loss of cholinergic neurons within the pedunculopontine tegmental nucleus (PPTg) in rats that had been intra-nigrally lesioned with the proteasomal inhibitor lactacystin, with levels of neuronal ...