Browsing Research Output by Author "10065318 - Du Plessis, Jeanetta"
Now showing items 1-20 of 52
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Bioactive albumin-based carriers for tumour chemotherapy
Shahzad, Yasser; Gerber, Minja; Du Plessis, Jeanetta; Khan, Ikram U.; Hussain, Talib (Bentham Science, 2014)Proteins are posed as the natural counterpart of the synthetic polymers for the development of drug delivery systems and few of them, have been regarded safe for drug delivery purposes by the United States Food and Drug ... -
Breaching the skin barrier through temperature modulations
Shahzad, Yasser; Louw, Ruaan; Gerber, Minja; Du Plessis, Jeanetta (Elsevier, 2015)The impermeability of the stratum corneum often hinders the transport of molecules across the skin. Temperature modulations in the skin and the application of local heat both have the potential of circumventing this problem ... -
Cutaneous tuberculosis overview and current treatment regimens
Van Zyl, Lindi; Du Plessis, Jeanetta; Viljoen, Joe (Elsevier, 2015)Tuberculosis is one of the oldest diseases known to humankind and it is currently a worldwide threat with 8e9 million new active disease being reported every year. Among patients with co-infection of the human immunodeficiency ... -
Determination of lovastatin, mevastatin, rosuvastatin and simvastatin with HPLC by means of gradient elution
Marais, S.; Du Preez, J.L.; Du Plessis, L.H.; Du Plessis, J.; Gerber, M. (Avoxa, 2019)A novel HPLC method with UV detection was developed and validated in skin penetration (in vitro) studies to identify and quantify lovastatin, mevastatin, rosuvastatin and simvastatin. A Venusil XBP C18 (2), 150 x 4.6 mm, ... -
Development and validation of the simultaneous determination of artemisone, clofazimine and decoquinate with HPLC
Du Preez, J.L.; Aucamp, M.E.; Burger, C.; Gerber, M.; Viljoen, J.M.; Van Zyl, L.; Du Plessis, J. (Avoxa, 2018)The aim of this study was to develop and validate a novel HPLC method for the simultaneous analysis of artemisone, clofazimine and decoquinate. Detection was obtained at two wavelengths; 284 nm (clofazimine) and 210 nm ... -
Development of a self-emulsifying drug delivery system for optimized topical delivery of clofazimine
Van Staden, Daniélle; Du Plessis, Jeanetta; Viljoen, Joe (MDPI, 2020)A quality-by-design and characterization approach was followed to ensure development of self-emulsifying drug delivery systems (SEDDSs) destined for topical delivery of the highly lipophilic clofazimine. Solubility and ... -
Development of topical/transdermal self-emulsifying drug delivery systems, not as simple as expected
Van Staden, Daniélle; Du Plessis, Jeanetta; Viljoen, Joe (MDPI, 2020)Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs. However, the revolutionary drug delivery ... -
Effect of emulsifiers and their liquid crystalline structures in emulsions on dermal and transdermal delivery of hydroquinone, salicylic acid and octadecenedioic acid
Otto, A.; Hadgraft, J.; Du Plessis, J.; Wiechers, J.W.; Kelly, C.L. (Karger, 2010)This study investigated the effect of emulsifiers and their liquid crystalline structures on the dermal and transdermal delivery of hydroquinone (HQ), salicylic acid (SA) and octadecenedioic acid (DIOIC). Emulsions containing ... -
Effect of penetration modifiers on the dermal and transdermal delivery of drugs and cosmetic active ingredients
Otto, A.; Hadgraft, J.; Du Plessis, J.; Wiechers, J.W.; Kelly, C.L. (Karger, 2008)In this study the effect of 2 penetration modifiers, dimethyl isosorbide (DMI) and diethylene glycol monoethyl ether (DGME) on the skin delivery of hydroquinone (HQ), salicylic acid (SA) and octadecenedioic acid (DIOIC) ... -
The effects of emulsifiers and emulsion formulation types on dermal and transdermal drug delivery
Otto, Anja; Du Plessis, Jeanetta (Springer, 2015)Emulsions are widely used in the cosmetic and pharmaceutical fields for the topical administration of hydrophilic and lipophilic active ingredients. There exist different types of emulsions, e.g. water-in-oil, oil-in-water, ... -
Essential fatty acids as transdermal penetration enhancers
Van Zyl, Lindi; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta; Viljoen, Joe (Elsevier, 2016)The aim of this study was to investigate the effect of different penetration enhancers, containing essential fatty acids (EFAs), on the transdermal delivery of flurbiprofen. Evening primrose oil (EPO), vitamin F and Pheroid™ ... -
Exploratory data analysis of the dependencies between skin permeability, molecular weight and log P
Kilian, D.; Lemmer, H.J.R.; Gerber, M.; Du Preez, J.L.; Du Plessis, J. (Govi-Verlag, 2016)Molecular weight and log P remain the most frequently used physicochemical properties in models that predict skin permeability. However, several reports over the past two decades have suggested that predictions made by ... -
Formulation and transdermal delivery of aciclovir and ketoconazole for HIV/AIDS patients
Jacobs, G.A.; Gerber, M.; Malan, M.M.; Du Preez, J.; Du Plessis, J. (Wiley, 2010)Due to their compromised immune systems, HIV/ AIDS- infected individuals are more susceptible to skin infections. Since fungal and viral cutaneous manifestations are frequently encountered in combination in HIV/AIDS patients, ... -
Formulation of natural oil nano-emulsions for the topical delivery of clofazimine, artemisone and decoquinate
Burger, Cornel; Aucamp, Marique; Du Preez, Jan; Haynes, Richard K.; Du Plessis, Jeanetta; Gerber, Minja (Springer, 2018)Purpose The aim of this study was to formulate nano-emulsions comprising natural oils and the active pharmaceutical ingredients (APIs) clofazimine (CLF), artemisone (ATM) and decoquinate (DQ) in order to determine ... -
In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells
Dwivedi, Anupma; Mazumder, Anisha; Du Plessis, Lissinda; Du Preez, Jan L.; Haynes, Richard K.; Du Plessis, Jeanetta (Elsevier, 2015)Artemisone is a 10-amino-artemisinin derivative that is markedly superior in vitro and in vivo to current artemisinins against malaria and also possesses antitumor activity. In seeking to capitalise on the last property, ... -
In vitro permeation of metals through human skin: a review and recommendations
Franken, Anja; Eloff, Frederik C.; Du Plessis, Jeanetta; Du Plessis, Johannes L. (American Chemical Society, 2015)During the last few decades, the interest in skin permeation of, specifically, metals has increased with the in vitro method utilizing diffusion cells as the prominent method of investigating permeability. This review ... -
In vitro permeation of platinum and rhodium through Caucasian skin
Franken, A.; Eloff, F.C.; Du Plessis, J.; Badenhorst, C.J.; Jordaan, A.; Du Plessis, J.L. (Elsevier, 2014)During platinum group metals (PGMs) refining the possibility exists for dermal exposure to PGM salts. The dermal route has been questioned as an alternative route of exposure that could contribute to employee sensitisation, ... -
In vitro permeation of platinum through African and Caucasian skin
Franken, A.; Eloff, F.C.; Du Plessis, J.; Badenhorst, C.J.; Du Plessis, J.L. (Elsevier, 2015)The majority of the South African workforce are Africans, therefore potential racial differences should be considered in risk and exposure assessments in the workplace. Literature suggests African skin to be a superior ... -
In vitro skin permeation of artemisone and its nano-vesicular formulations
Dwivedi, Anupma; Mazumder, Anisha; Fox, Lizelle T.; Brümmer, Alicia; Gerber, Minja; Du Preez, Jan L.; Haynes, Richard K.; Du Plessis, Jeanetta (Elsevier, 2016)The artemisinin derivative artemisone has antitumor activity. In particular when encapsulated in solid lipid nanoparticles (SLNs) and niosomes, it is active against human melanoma A-375 cells, although such formulations ... -
In vitro skin permeation of sinigrin from its phytosome complex
Mazumder, Anisha; Dwivedi, Anupma; Fox, Lizelle T.; Brümmer, Alicia; Du Preez, Jan L.; Gerber, Minja; Du Plessis, Jeanetta (Wiley, 2016)Objectives: Sinigrin is a major glucosinolate present in plants of the Brassicaceae family. Recently sinigrin and its phytosome formulations have been investigated for its wound healing actions, by our research group. The ...