Browsing Research Output by Author "10477438 - Mathews, Edward Henry"
Now showing items 1-20 of 26
-
Can successful cancer therapies build on what we learn from complex disorders?
Mathews, Edward Henry; Liebenberg, Leon (Elsevier, 2012) -
Case study: the effects of a variable flow energy saving strategy on a deep-mine cooling system
Du Plessis, Gideon Edgar; Liebenberg, Leon; Mathews, Edward Henry (Elsevier, 2013)Cooling systems consume up to 25% of the total electricity used on deep level mines. These systems are integrated with the water reticulation system to provide chilled service water to the mine as well as cooling for mine ... -
The design and development of a stented tissue mitral and aortic heart valve replacement for human implantation
Legg, Murray; Mathews, Edward; Pelzer, Ruaan (Clinics Cardive, 2012)A study was conducted into the development of a mitral and aortic heart valve replacement that caters for patients having suffered valve damage due to stenosis or rheumatic fever. The appeal of the valve is that it is ... -
Developing esco procedures for large telecommunication facilities using novel simulation techniques
Van Rensburg, J.F.; Geyser, M.F.; Kleingeld, M.; Mathews, E.H. (Energy Research Centre, University of Cape Town, 2008)Peak electricity demand in South Africa will exceed the available operational generation capacity in 2007. The state utility, Eskom, is addressing this challenge, inter alia, with the implementation of a national Demand-side ... -
Flow over a glider canopy
Jonker, A.S.; Bosman, J.J.; Mathews, E.H.; Liebenberg, L. (Royal Aeronautical Society, 2014)In order to minimise drag, the front part of most modern glider fuselages is shaped so that laminar flow is preserved to a position close to the wing-to-fuselage junction. Experimental investigations on a full-scale JS1 ... -
High-glycolytic cancers and their interplay with the body's glucose demand and supply cycle
Mathews, Edward Henry; Liebenberg, Leon; Pelzer, Ruaan (Elsevier, 2011)Many difficult-to-treat solid cancer tumours and metastases have high-glucose uptake, usually under hypoxic conditions. Hypoxic tumours suppress the immune system and are insensitive to traditional chemoradiotherapies. The ... -
How do high glycemic load diets influence coronary heart disease?
Mathews, Marc J.; Liebenberg, Leon; Mathews, Edward H. (BioMed Central, 2015)Background: Diet has a significant relationship with the risk of coronary heart disease (CHD). Traditionally the effect of diet on CHD was measured with the biomarker for low-density lipoprotein (LDL) cholesterol. However, ... -
A hypothetical method for controlling highly glycolytic cancers and metastases
Mathews, Edward H.; Mathews, George E.; Meyer, Albertus A. (Elsevier, 2018)Most proliferating cancer cells and cancer-associated tumor stroma have an upregulated glucose energy demand in relation to normal cells. Cancer cells are further less metabolically flexible than normal cells. They can ... -
Industry 4.0 roll-out strategy for dynamic mine heat load management
Nell, D.; Mathews, E.H.; Maré, P. (Stellenbosch Univ, 2019)Deep-level mining is under severe financial pressure from several unique challenges. One of these is maintaining acceptable underground temperatures for humans to work in while achieving demanding production targets. ... -
Influence of partial and complete glutamine-and glucose deprivation of breast-and cervical tumorigenic cell lines
Visagie, Michelle Helen; Liebenberg, Leon; Mathews, Edward Henry; Mathews, George Edward; Mqoco, Thandi Vuyelwa (BioMed Central, 2015)Background: Due to their high proliferative requirements, tumorigenic cells possess altered metabolic systems whereby cells utilize higher quantities of glutamine and glucose. These altered metabolic requirements make it ... -
The integrated effect of moderate exercise on coronary heart disease
Mathews, M.J.; Mathews, E.H.; Mathews, G.E. (Clinics Cardive, 2017)Background: Moderate exercise is associated with a lower risk for coronary heart disease (CHD). A suitable integrated model of the CHD pathogenetic pathways relevant to moderate exercise may help to elucidate this association. ... -
Integrated energy optimisation for the cement industry: a case study perspective
Swanepoel, Jan Adriaan; Mathews, Edward Henry; Vosloo, Jan; Liebenberg, Leon (Elsevier, 2014)Energy costs play a major role in the cement production process. As much as 60% of total cost is allocated to energy and 18% to the consumption of electrical energy. Historically, energy cost savings were achieved by ... -
The mechanism by which moderate alcohol consumption influences coronary heart disease
Mathews, Marc J.; Liebenberg, Leon; Mathews, Edward H. (BioMed Central, 2015)Background Moderate alcohol consumption is associated with a lower risk for coronary heart disease (CHD). A suitably integrated view of the CHD pathogenesis pathway will help to elucidate how moderate alcohol consumption ... -
The mechanisms by which antidepressants may reduce coronary heart disease risk
Mathews, Marc J.; Mathews, Edward H.; Liebenberg, Leon (BioMed Central, 2015)Background Depression is known to increase the risk for coronary heart disease (CHD) likely through various pathogenetic actions. Understanding the links between depression and CHD and the effects of mediating these links ... -
A new approach to ensure successful implementation of sustainable demand side management (DSM) in South African mines
Pelzer, R.; Mathews, E.H.; Le Roux, D.F.; Kleingeld, M. (Elsevier, 2008)Demand side management (DSM) is seen as a short-term solution to the imminent problem of electricity supply shortages in South Africa. DSM aims to reduce peak loads with immediate results in a short time. The mining sector ... -
A new model to estimate Bolus insulin need
Mathews, Edward H.; Pelzer, Ruaan (Mary Ann Liebert, Inc, 2009)Patients with type 1 diabetes usually use the carbohydrate (CHO) counting method to establish their bolus insulin need. However, most still struggle with blood glucose control. We believe that for good control their insulin ... -
On the wing density and the inflation factor of aircraft
Huyssen, R.J.; Mathews, E.H.; Liebenberg, L.; Spedding, G.R. (Royal Aeronautical Soc, 2016)The aviation industry is dominated by the domain of heavier-than-air, fixed-wing, subsonic flight, and central to any design in this domain is the wing itself. One of the earliest debates in aviation still centres around ... -
Optimisation of a storage facility used to effect power control in the PBMR power cycle
Matimba, A.; Mathews, E.H.; Pelzer, R. (SAIMechE, 2008)This article presents the optimization of a gas storage facility used to effect power control in South Africa's PBMR power cycle. It was shown in the article, a multitank storage facility to affect power control in the ... -
Oral health and coronary heart disease
Mathews, Marc J.; Mathews, Edward H.; Mathews, George E. (BioMed Central, 2016)Background: It is well documented that there is some correlation between poor oral health in the form of periodontal disease and coronary heart disease (CHD). It is unclear whether this correlation is due to a ... -
A practical approach to managing uncertainty in the measurement and verification of energy efficiency savings
Hamer, W.; Booysen, W.; Mathews, E.H. (Univ Stellenbosch, 2017)Measurement and verification (M&V) is fundamental in determining the impact of energy efficiency (EE) interventions. However, accurately quantifying the EE savings on complex industrial systems can present several ...