Browsing Research Output by Author "11083417 - Harvey, Brian Herbert"
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Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders
Zabegalov, Konstantin N.; Harvey, Brian H.; Khatsko, Sergey L.; Lakstygal, Anton M.; Demin, Konstantin A. (Elsevier, 2019)Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence ... -
Adverse neuropsychiatric events and recreational use of efavirenz and other HIV-1 antiretroviral drugs
Dalwadi, Dhwanil A.; Harvey, Brian H.; Viljoen, Michelle; Ozuna, Luis; Schetz, John A. (ASPET, 2018)Efavirenz is a highly effective HIV-1 antiretroviral; however, it is also frequently associated with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep disturbances, nervousness, anxiety, depression, ... -
The ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in rats
Hamlyn, Eugene; Brand, Linda; Harvey, Brian H.; Shadid, Mohammed (Wolters Kluwer, 2009)Ampakines have shown beneficial effects on cognition in selected animal models of learning. However, their ability to modify long-term spatial memory tasks has not been studied yet. This would lend credence to their possible ... -
Animal models of major depressive disorder and the implications for drug discovery and development
Demin, Konstantin A.; Harvey, Brian H.; Sysoev, Maxim; Chernysh, Maria V.; Savva, Anna K. (Taylor & Francis, 2019)Introduction: Depression is a highly debilitating psychiatric disorder that affects the global population and causes severe disabilities and suicide. Depression pathogenesis remains poorly understood, and the disorder is ... -
Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression
Liebenberg, Nico; Harvey, Brian H.; Brand, Linda; Brink, Christiaan B. (Wolters Kluwer, 2010)We explored the antidepressant-like properties of two phosphodiesterase type 5 (PDE5) inhibitors in a genetic animal model of depression, namely Flinders sensitive line rats. We investigated the dose-dependency of the ... -
Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies
Brink, C.B.; Clapton, J.D.; Eagar, B.E.; Harvey, B.H. (Springer, 2008)The phosphodiesterase (PDE) 5 inhibitor sildenafil has been shown to display psychotropic actions in humans and animals, and has been used for the treatment of antidepressant-associated erectile dysfunction. However, its ... -
Appraisal of ozone as biologically active molecule and experimental tool in biomedical sciences
Mokoena, Mmalebuso L.; Brink, Christiaan B.; Harvey, Brian H.; Oliver, Douglas W. (Springer, 2011)Ozone (O3) (CAS 10028-15-6) is a major air industrial pollutant and is well known for its very strong oxidative actions which affords the molecule its useful antimicrobial and deodorizing properties, but also its potential ... -
Attenuated brain-derived neurotrophic factor and hypertrophic remodelling: the SABPA study
Smith, A.J.; Malan, L.; Uys, A.S.; Malan, N.T.; Harvey, B.H. (Springer Nature, 2015)Brain-derived neurotrophic factor (BDNF) has been linked to neurological pathologies, but its role in cardiometabolic disturbances is limited. We aimed to assess the association between serum BDNF levels and structural ... -
Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties
Delport, Anzelle; Harvey, Brian H.; Petzer, Anél; Petzer, Jacobus P. (Elsevier, 2014)Aims: The phenothiazinium compound, methylene blue (MB), possesses diverse pharmacological actions and is attracting attention for the treatment of bipolar disorder and Alzheimer's disease. MB acts on both monoamine oxidase ... -
Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase
Petzer, Anél; Harvey, Brian H.; Petzer, Jacobus P.; Wegener, Gregers (Elsevier, 2012)Methylene blue (MB) has been shown to act at multiple cellular and molecular targets and as a result possesses diverse medical applications. Among these is a high potency reversible inhibition of monoamine oxidase A ... -
Bio-behavioural studies into the antidepressant and antipsychotic-like effects of Garcinia mangostana Linn extract and alpha-mangostin as adjunctive-or mono-therapy in a rodent model of schizophrenia
Harvey, B.H.; Möller, M.; Lötter, J.; Dean, O.; Berk, M. (Wiley, 2019)Introduction: Garcinia mangostana Linn (GML) or mangosteen has anti-inflammatory, antioxidant and neuroprotective actions. Its bioactive constituents, α- , β- , and γ- mangostin also inhibit cAMP ... -
Blunted neuro-endocrine responses linking depressive symptoms and ECG left ventricular hypertrophy in black Africans: the SABPA study
Mashele, Nyiko; Malan, Leoné; Van Rooyen, Johannes M.; Harvey, Brian H.; Potgieter, Johan C.; Hamer, Mark (Wolters Kluwer, 2014)Objective: Chronic psychosocial stress as experienced in an urban environment plays an important role in the aetiology of depression-related cardiovascular risk. It is uncertain whether acute mental stress responses aggravate ... -
Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathology
Daniels, Willie M.U.; Savitz, Jonathan (Cambridge Univ Press, 2008)While monoaminergic hypotheses of psychopathology remain popular, there has been growing interest in the role of neurotrophins in neuropsychiatric disorders. Basic laboratory work has documented the importance of neurotrophins ... -
Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: the SABPA study
Malan, Leoné; Hamer, Mark; Von Känel, Roland; Harvey, Brian H.; Steyn, Faans; Malan, Nico T. (Elsevier, 2016)Background Depression has been associated with impaired nitric oxide (NO)-mediated vasodilation and vascular dysregulation (VD). Whether depression and NO levels will disturb retinal haemodynamics is not clear. Objectives ... -
Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats
Liebenberg, Nico; Harvey, Brian H.; Brand, Linda; Brink, Christiaan B.; Wegener, Gregers (Springer, 2012)There are conflicting results from behavioural studies regarding whether the activation or inhibition of the cGMP-nitric oxide (NO) pathway induces anxiolytic-like behaviour. Sildenafil, an inhibitor of cGMP-selective ... -
Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: attenuation after chronic fluoxetine treatment
Korff, Schaun; Harvey, Brian H.; Stein, Dan J. (Elsevier, 2009)Motor stereotypies, described as repetitive, topographically invariant and seemingly purposeless behaviours, are common to several developmental and neuropsychiatric disorders. While drug induced stereotypy has been ... -
Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse
Güldenpfennig, Marianne; Wolmarans, De Wet; Du Preez, Jan L.; Harvey, Brian H.; Stein, Dan J. (Elsevier, 2011)The deer mouse presents with spontaneous stereotypic movements that resemble the repetitive behaviours of obsessive–compulsive disorder (OCD), and demonstrates a selective response to serotonin reuptake inhibitors. OCD has ... -
Corticolimbic changes in acetylcholine and cyclic guanosine monophosphate in the Flinders Sensitive Line rat: a genetic model of depression
Brand, Linda; Van Zyl, Jurgens; Minnaar, Estella L.; Viljoen, Francois; Du Preez, Jan L.; Harvey, Brian H. (Cambridge, 2012)Objective: Depression is suggested to involve disturbances in cholinergic as well as glutamatergic pathways, particularly the N-methyl-d-aspartate receptor-mediated release of nitric oxide (NO) and cyclic guanosine ... -
A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: mapping the way forward
De Brouwer, Geoffrey; Fick, Arina; Harvey, Brian H.; Wolmarans, De Wet (Springer, 2019)Rodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or measure to study anxiety- and compulsive-like behaviors or anxiolytic and anticompulsive drug action. However, the test responds ... -
Cross-species analyses of intra-species behavioral differences in mammals and fish
Demin, Konstantin A.; Harvey, Brian H.; Lakstygal, Anton M.; Volgin, Andrey D.; De Abreu, Murilo S. (Elsevier, 2020)Multiple species display robust behavioral variance among individuals due to different genetic, genomic, epigenetic, neuroplasticity and environmental factors. Behavioral individuality has been extensively studied in various ...