Browsing Research Output by Author "11329025 - Gerber, Minja"
Now showing items 1-20 of 33
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Bioactive albumin-based carriers for tumour chemotherapy
Shahzad, Yasser; Gerber, Minja; Du Plessis, Jeanetta; Khan, Ikram U.; Hussain, Talib (Bentham Science, 2014)Proteins are posed as the natural counterpart of the synthetic polymers for the development of drug delivery systems and few of them, have been regarded safe for drug delivery purposes by the United States Food and Drug ... -
Breaching the skin barrier through temperature modulations
Shahzad, Yasser; Louw, Ruaan; Gerber, Minja; Du Plessis, Jeanetta (Elsevier, 2015)The impermeability of the stratum corneum often hinders the transport of molecules across the skin. Temperature modulations in the skin and the application of local heat both have the potential of circumventing this problem ... -
Determination of lovastatin, mevastatin, rosuvastatin and simvastatin with HPLC by means of gradient elution
Marais, S.; Du Preez, J.L.; Du Plessis, L.H.; Du Plessis, J.; Gerber, M. (Avoxa, 2019)A novel HPLC method with UV detection was developed and validated in skin penetration (in vitro) studies to identify and quantify lovastatin, mevastatin, rosuvastatin and simvastatin. A Venusil XBP C18 (2), 150 x 4.6 mm, ... -
Development and validation of the simultaneous determination of artemisone, clofazimine and decoquinate with HPLC
Du Preez, J.L.; Aucamp, M.E.; Burger, C.; Gerber, M.; Viljoen, J.M.; Van Zyl, L.; Du Plessis, J. (Avoxa, 2018)The aim of this study was to develop and validate a novel HPLC method for the simultaneous analysis of artemisone, clofazimine and decoquinate. Detection was obtained at two wavelengths; 284 nm (clofazimine) and 210 nm ... -
Essential fatty acids as transdermal penetration enhancers
Van Zyl, Lindi; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta; Viljoen, Joe (Elsevier, 2016)The aim of this study was to investigate the effect of different penetration enhancers, containing essential fatty acids (EFAs), on the transdermal delivery of flurbiprofen. Evening primrose oil (EPO), vitamin F and Pheroid™ ... -
Exploratory data analysis of the dependencies between skin permeability, molecular weight and log P
Kilian, D.; Lemmer, H.J.R.; Gerber, M.; Du Preez, J.L.; Du Plessis, J. (Govi-Verlag, 2016)Molecular weight and log P remain the most frequently used physicochemical properties in models that predict skin permeability. However, several reports over the past two decades have suggested that predictions made by ... -
Formulation and transdermal delivery of aciclovir and ketoconazole for HIV/AIDS patients
Jacobs, G.A.; Gerber, M.; Malan, M.M.; Du Preez, J.; Du Plessis, J. (Wiley, 2010)Due to their compromised immune systems, HIV/ AIDS- infected individuals are more susceptible to skin infections. Since fungal and viral cutaneous manifestations are frequently encountered in combination in HIV/AIDS patients, ... -
Formulation of natural oil nano-emulsions for the topical delivery of clofazimine, artemisone and decoquinate
Burger, Cornel; Aucamp, Marique; Du Preez, Jan; Haynes, Richard K.; Du Plessis, Jeanetta; Gerber, Minja (Springer, 2018)Purpose The aim of this study was to formulate nano-emulsions comprising natural oils and the active pharmaceutical ingredients (APIs) clofazimine (CLF), artemisone (ATM) and decoquinate (DQ) in order to determine ... -
In vitro skin permeation of artemisone and its nano-vesicular formulations
Dwivedi, Anupma; Mazumder, Anisha; Fox, Lizelle T.; Brümmer, Alicia; Gerber, Minja; Du Preez, Jan L.; Haynes, Richard K.; Du Plessis, Jeanetta (Elsevier, 2016)The artemisinin derivative artemisone has antitumor activity. In particular when encapsulated in solid lipid nanoparticles (SLNs) and niosomes, it is active against human melanoma A-375 cells, although such formulations ... -
In vitro skin permeation of sinigrin from its phytosome complex
Mazumder, Anisha; Dwivedi, Anupma; Fox, Lizelle T.; Brümmer, Alicia; Du Preez, Jan L.; Gerber, Minja; Du Plessis, Jeanetta (Wiley, 2016)Objectives: Sinigrin is a major glucosinolate present in plants of the Brassicaceae family. Recently sinigrin and its phytosome formulations have been investigated for its wound healing actions, by our research group. The ... -
In vitro wound healing and cytotoxic activity of the gel and whole-leaf materials from selected aloe species
Fox, Lizelle T.; Mazumder, Anisha; Dwivedi, Anupma; Gerber, Minja; Du Plessis, Jeanetta; Hamman, Josias H. (Elsevier, 2017)Ethnopharmacological relevance Aloe vera is one of the most important medicinal plants in the world with applications in the cosmetic industry and also in the tonic or health drink product market. Different parts of Aloe ... -
In vivo skin hydration and anti-erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications
Fox, Lizelle T.; Du Plessis, Jeanetta; Gerber, Minja; Van Zyl, Sterna; Boneschans, Banie; Hamman, Josias H. (Medknow, 2014)To investigate the skin hydrating and anti-erythema activity of gel materials from Aloe marlothii A. Berger and A. ferox Mill. in comparison to that of Aloe barbadensis Miller (Aloe vera) in healthy human volunteers. ... -
A novel HPLC method developed and validated for the detection and quantification of atorvastatin, fluvastatin, pitavastatin and pravastatin during transdermal delivery studies
Maree, Sumari; Du Preez, Jan L.; Du Plessis, Lissinda H.; Du Plessis, Jeanetta; Gerber, Minja (Govi-Verlag, 2020)An HPLC method was developed and validated to quantify and identify several statins (atorvastatin, fluvastatin, pitavastatin and pravastatin) that were used during transdermal drug delivery. The method proved to be most ... -
A novel RP-HPLC method for the detection and quantification of roxithromycin in topical delivery studies
Aucamp, M.E.; Csongradi, C.; Gerber, M.; Du Plessis, J. (Govi-Verlag, 2015)A novel HPLC method with UV detection for the identification and quantification of roxithromycin (ROX) during in vitro skin penetration studies has been developed and validated. The method proved to be simple and rapid ... -
Optimised transdermal delivery of pravastatin
Burger, Cornel; Gerber, Minja; Du Preez, Jan L.; Du Plessis, Jeanetta (Elsevier, 2015)Wiechers’ programme “Formulating for Efficacy” initiated a new strategy to optimise the oil phase of topical formulations in order to achieve optimal transdermal drug delivery. This new approach uses the “Delivery Gap ... -
Penetration enhancing effects of selected natural oils utilized in topical dosage forms
Viljoen, Joe M.; Cowley, Amé; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta (Taylor & Francis, 2015)Context: Various natural products, including oils, have been utilized as penetration enhancers due to their “safety profiles”. These oils contain fatty acids promoting skin permeability through lipid fluidization within ... -
Physical stability and clinical efficacy of Crocodylus niloticus oil lotion
Venter, Telanie; Fox, Lizelle Trifena; Gerber, Minja; Du Preez, Jan L.; Van Zyl, Sterna; Boneschans, Banie; Du Plessis, Jeanetta (Elsevier, 2016)The stability and the anti-ageing, skin hydrating and anti-erythema effects of a commercialized Crocodylus niloticus oil lotion was determined. The lotion was stored at controlled conditions over six months during which ... -
Review of natural compounds for potential skin cancer treatment
Chinembiri, Tawona N.; Du Plessis, Lissinda H.; Gerber, Minja; Hamman, Josias H.; Du Plessis, Jeanetta (MDPI, 2014)Most anti-cancer drugs are derived from natural resources such as marine, microbial and botanical sources. Cutaneous malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. Various ... -
Skin permeation enhancement effects of the gel and whole 1 leaf materials of A. vera, A. marlothii and A. ferox
Fox, Lizelle T.; Gerber, Minja; Du Preez, Jan L.; Du Plessis, Jeanetta; Hamman, Josias H. (Wiley, 2015)Objectives: The aim of this study was to investigate the in vitro permeation enhancement effects of the gel and whole leaf materials of Aloe vera, Aloe marlothii and Aloe ferox using ketoprofen as a marker compound. Methods: ... -
Stability, clinical efficacy and antioxidant properties of honeybush extracts in semi-solid formulations.
Gerber, Gezina S.F.W.; Fox, Lizelle T.; Gerber, Minja; Du Preez, Jan L.; Van Zyl, Sterna; Boneschans, Banie; Du Plessis, Jeanetta (Medknow Publications, 2015)Background: Honeybush extracts (Cyclopia spp.) can be incorporated into skin care products to treat conditions such as skin dryness and can function as an anti-oxidant. Objective: To formulate Honeybush formulations and ...