Browsing Research Output by Author "11775416 - Viljoen, Francois Petrus"
Now showing items 1-11 of 11
-
Corticolimbic changes in acetylcholine and cyclic guanosine monophosphate in the Flinders Sensitive Line rat: a genetic model of depression
Brand, Linda; Van Zyl, Jurgens; Minnaar, Estella L.; Viljoen, Francois; Du Preez, Jan L.; Harvey, Brian H. (Cambridge, 2012)Objective: Depression is suggested to involve disturbances in cholinergic as well as glutamatergic pathways, particularly the N-methyl-d-aspartate receptor-mediated release of nitric oxide (NO) and cyclic guanosine ... -
The design and evaluation of an l-dopa-lazabemide prodrug for the treatment of Parkinson’s disease
Hoon, Monique; Petzer, Jacobus P.; Viljoen, Francois; Petzer, Anél (MDPI, 2017)l-Dopa, the metabolic precursor of dopamine, is the treatment of choice for the symptomatic relief of the advanced stages of Parkinson’s disease. The oral bioavailability of l-dopa, however, is only about 10% to 30%, and ... -
Development and validation of a HPLC electrochemical detection method to measure COMT activity as a tool in drug development
Viljoen, F.P.; Du Preez, J.L.; Petzer, A.; Wessels, J.C.; Petzer, J. (Avoxa, 2019)The determination of catechol-O-methyltransferase (COMT) activity is considered valuable for various pharmaceutical and biomedical research projects. A specific high performance liquid chromatography-coulometric electrochemical ... -
Guidelines to minimise human error in South African laboratories with regard to therapeutic drug monitoring
Viljoen, F.P.; Rheeders, M.; Brand, L.; Du Preez, J.L. (SMLTSA, 2016)Therapeutic drug monitoring (TDM) fulfils an important function in patient health in both the public and private healthcare systems. TDM is based on pharmacokinetic principles within the clinical laboratory and several ... -
HPLC electrochemical detection and quantification of monoamines and their metabolites in rat brain tissue samples
Viljoen, F.P.; Du Preez, J.L.; Wessels, J.C.; Aucamp, M.E. (Avoxa, 2018)The monitoring of monoamines and their metabolites in CNS samples can be very valuable in pharmaceutical and biomedical research. A specific high performance liquid chromatography, coupled to a coulometric electrochemical ... -
An HPLC-DAD validated method for the detection and quantification of cortisol, corticosterone and melatonin in plasma samples of two different animal species
Viljoen, F.P.; Du Preez, J.L.; Wessels, J.C.; Aucamp, M.E.; Meyer, L.C.R.; Pohlin, F. (Avoxa, 2019)The monitoring of endogenous hormone plasma levels could be valuable in biomedical, veterinary and pharmaceutical research. A specific high performance liquid chromatography method with diode array detection, for the assay ... -
N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
Möller, Marisa; Du Preez, Jan L.; Viljoen, Francois P.; Harvey, Brian H.; Berk, Michael (Springer, 2013)Schizophrenia is causally associated with early-life environmental stress, implicating oxidative stress in its pathophysiology. N-acetyl cysteine (NAC), a glutathione precursor and antioxidant, is emerging as a useful ... -
An optimized method for the analysis of corticosterone in rat plasma by UV-HPLC
Viljoen, F.P.; Brand, L.; Smit, E.J. (Society of Medical Laboratory Technologists of SA, 2012)Animal models are useful in the study of stress disorders in that they offer the possibility of stimulating a human condition under controlled conditions in a simpler, more readily understandable system. Stress-related ... -
Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response
Mokoena, Mmalebuso L.; Harvey, Brian H.; Viljoen, Francois; Ellis, Susanna M.; Brink, Christiaan B. (Springer, 2015)Rationale Major depression has been associated with higher levels of air pollution that in turn leads to neurodegeneration via increased oxidative stress. There is a need for suitable translational animal models to study ... -
Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues
Harvey, Brian H.; Duvenhage, Ingrid; Viljoen, Francois; Scheepers, Nellie; Brink, Christiaan B.; Petzer, Jacobus P.; Malan, Sarel F. (Elsevier, 2010)Dual action antidepressants have important therapeutic implications. Methylene blue (MB), a charged compound structurally related to tricyclic antidepressants, acts on both monoamine oxidase (MAO) and the nitric oxide ... -
Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
Möller, Marisa; Du Preez, Jan L.; Viljoen, Francois P.; Harvey, Brian H.; Berk, Michael; Emsley, Robin (Elsevier, 2013)Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and immune-inflammatory abnormalities, evidenced by oxidative stress, altered kynure nine metaboli sm and cytokine release . N-acetyl cysteine ...