Browsing Research Output by Author "21069565 - Meiring, Letitia"
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C6- and C7-substituted 3,4-dihydro-2(1H)-quinolinones as inhibitors of monoamine oxidase
Meiring, Letitia; Petzer, Jacobus Petrus; Petzer, Anél (Thieme, 2017)Purpose Monoamine oxidase (MAO) inhibitors are considered to be useful therapeutic agents and isoform specific inhibitors are employed for the treatment of depression and Parkinson’s disease. MAO inhibitors are also under ... -
Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives
Meiring, Letitia; Petzer, Jacobus P.; Petzer, Anél (Elsevier, 2013)In the present study, a series of 3,4-dihydro-2(1H)-quinolinone derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 3,4-dihydro-2(1H)- quinolinone derivatives ... -
A review of the pharmacological properties of 3,4-dihydro-2(1h)- quinolinones
Meiring, Letitia; Petzer, Jacobus P.; Petzer, Anél (Bentham Science, 2018)The 3,4-dihydro-2(1H)-quinolinone moiety is present in a number of pharmacologically active compounds. These include FDA approved drugs such as cilostazol, carteolol and aripiprazole as well as numerous experimental ...