Browsing Research Output by Author "Aucamp, Marique"
Now showing items 1-11 of 11
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Amorphous azithromycin with improved aqueous solubility and intestinal membrane permeability
Aucamp, Marique; Odendaal, Roelf; Liebenberg, Wilna; Hamman, Josias (Taylor & Francis, 2015)Azithromycin (AZM) is a poorly soluble macrolide antibacterial agent. Its low solubility is considered as the major contributing factor to its relatively low oral bioavailability. The aim of this study was to improve the ... -
Amorphous sulfadoxine: a physical stability and crystallization kinetics study
Aucamp, Marique; Milne, Marnus; Liebenberg, Wilna (Springer Nature, 2016)Poor aqueous solubility of drugs and the improvement thereof has always been a challenge for the pharmaceutical industry.With this, one of the focuses of the pharmaceutical research scientist involves investigating ... -
Co-crystals of the antiretroviral nevirapine: crystal structures, thermal analysis and dissolution behaviour
Caira, Mino R.; Liebenberg, Wilna; Stieger, Nicole; Aucamp, Marique; Bourne, Susan A. (RSC, 2012)Synthesis and physicochemical characterization of co-crystals of the antiretroviral drug nevirapine (NV) with the pharmaceutically acceptable co-formers saccharin, rac-tartaric acid, maleic acid, glutaric acid and salicylic ... -
Formulation of natural oil nano-emulsions for the topical delivery of clofazimine, artemisone and decoquinate
Burger, Cornel; Aucamp, Marique; Du Preez, Jan; Haynes, Richard K.; Du Plessis, Jeanetta; Gerber, Minja (Springer, 2018)Purpose The aim of this study was to formulate nano-emulsions comprising natural oils and the active pharmaceutical ingredients (APIs) clofazimine (CLF), artemisone (ATM) and decoquinate (DQ) in order to determine ... -
Inulin suitable as reduced-kilojoule carrier for production of microencapsulated spray-dried green Cyclopia subternata (honeybush) extract
Pauck, Claire; Aucamp, Marique; Liebenberg, Wilna; Stieger, Nicole; De Beer, Dalene (Elsevier, 2017)Retention of phenolic compounds during spray-drying of an anti-diabetic C. subternata extract and physicochemical characteristics of spray-dried powders (pure extract and extract-carrier mixtures) were evaluated. Extract-carrier ... -
A novel RP-HPLC method for the detection and quantification of clarithromycin or spiramycin in bulk drug samples and dosage forms
Katsidzira, Runako Masline; Wessels, Anita; Aucamp, Marique (Innovare Academic Sciences, 2016)Objective: This study was aimed at developing an HPLC method that would be suitable and sufficiently robust to analyze clarithromycin or spiramycin from bulk materials, amorphous solid dispersions as well as when included ... -
Phenolic and physicochemical stability of a functional beverage powder mixture during storage: effect of the microencapsulant inulin and food ingredients
De Beer, Dalene; Aucamp, Marique; Liebenberg, Wilna; Stieger, Nicole; Pauck, Claire E. (Wiley, 2018)BACKGROUND The need for a convenience herbal iced tea product with reduced kilojoules merited investigation of the shelf-life of powder mixtures containing a green Cyclopia subternata Vogel (honeybush) extract with proven ... -
Physicochemical properties of amorphous roxithromycin prepared by quench cooling of the melt or desolvation of a chloroform solvate
Aucamp, Marique; Liebenberg, Wilna; Strydom, Schalk J.; Van Tonder, Elsa C.; De Villiers, Melgardt M. (Springer, 2012)Roxithromycin is a poorly soluble antibacterial drug. The aim of this study was to prepare and characterize an amorphous form of roxithromycin. The amorphous form was prepared by desolvation of its chloroform solvate, and ... -
Solution-mediated phase transformation of different roxithromycin solid-state forms: implications on dissolution and solubility
Aucamp, Marique; Stieger, Nicole; Barnard, Neil; Liebenberg, Wilna (Elsevier, 2013)The objective of this study was to describe the solid-state forms in which roxithromycin may exist and the significant influence of solution-mediated phase transformation on the dissolution and solubility behavior of ... -
The stabilization of amorphous zopiclone in an amorphous solid dispersion
Milne, Marnus; Liebenberg, Wilna; Aucamp, Marique (Springer, 2015)Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and characterize an amorphous form of zopiclone as well as the characterization and performance of a stable amorphous solid ... -
Treatment modalities for acne
Fox, Lizelle; Csongradi, Candice; Aucamp, Marique; Du Plessis, Jeanetta; Gerber, Minja (MDPI, 2016)Acne is a common inflammatory skin disease which affects the pilosebaceous units of the skin. It can have severe psychological effects and can leave the patient with severe skin scarring. There are four well-recognized ...