Browsing Research Output by Author "Badenhorst, Christoffel Petrus Stephanus"
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Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation
Badenhorst, Christoffel Petrus Stephanus; Erasmus, Elardus; Van der Sluis, Rencia; Van Dijk, Alberdina Aike (Taylor & Francis, 2013)Introduction: Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C. 2.3.1.13), is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A ... -
A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids
Badenhorst, Christoffel Petrus Stephanus; Erasmus, Elardus; Van der Sluis, Rencia; Nortje, Carla; Van Dijk, Alberdina Aike (Taylor & Francis, 2014)A number of endogenous and xenobiotic organic acids are conjugated to glycine, in animals ranging from mosquitoes to humans. Glycine conjugation has generally been assumed to be a detoxification mechanism, increasing the ...