Browsing Research Output by Subject "Biomarkers"
Now showing items 1-10 of 24
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The African prospective study on the early detection and identification of cardiovascular disease and hypertension (African-PREDICT): design, recruitment and initial examination
(Sage, 2019)Background: Globally hypertension is stabilising, but in sub-Saharan Africa the incidence of hypertension remains on an increase. Although this might be attributed to poor healthcare and ineffective antihypertensive ... -
The application of metabolomics toward pulmonary tuberculosis research
(Elsevier, 2019)In the quest to identify novel biomarkers for pulmonary tuberculosis (TB), high-throughput systems biology approaches such as metabolomics has become increasingly widespread. Such biomarkers have not only successfully been ... -
Assessing tobacco use in an African population: serum and urine cotinine cut-offs from South Africa
(Elsevier, 2019)Background Cotinine, a nicotine metabolite, is used to measure tobacco use and exposure, but recommended cut-offs to differentiate tobacco users from those exposed through the environment range from 3 to 58 ng/ml in serum, ... -
Baseline bio-accumulation concentrations and resulting oxidative stress in Synodontis zambezensis after an acute laboratory exposure to 4,4′-DDT
(Elsevier, 2019)The use of 1,1′-(2,2,2-Trichloro-1,1-ethanediyl)bis(4-chlorobenzene) (DDT) as a pesticide for the control of insects vectors responsible for the spread of many life threatening diseases was officially banned in 1972 by the ... -
Ecotoxicity of mine tailings: unrehabilitated versus rehabilitated
(Springer, 2018)Earthworms are bioindicators of soil pollution. The ecotoxicity of tailings from selected gold mines in South Africa was investigated utilizing Eisenia andrei bioassays and biomarkers. Samples were obtained from unrehabilitated, ... -
Effects of exercise on alterations in redox homeostasis in elite male and female endurance athletes using a clinical point-of-care test
(Canadian Science Publishing, 2016)Exercise causes alterations in redox homeostasis (ARH). Measuring ARH in elite athletes may aid in the identification of training tolerance, fatigued states, and underperformance. To the best of our knowledge, no studies ... -
Effects of the organochlorine p,p’-DDT on MCF-7 cells: investigating metabolic and immune modulatory transcriptomic changes
(Elsevier, 2019)The organochlorine pesticide dichloro-diphenyl-trichloroethane (DDT) is persistent in the environment and leadsto adverse human health effects. High levels in breast milk pose a threat to both breast tissue and nursing ... -
The GC-MS metabolomics signature in patients with fibromyalgia syndrome directs to dysbiosis as an aspect contributing factor of FMS pathophysiology
(Springer, 2019)Introduction Fibromyalgia syndrome (FMS) is a chronic pain syndrome. Previous analyses of untargeted metabolomics data indicated altered metabolic profile in FMS patients. Objectives We report a semi-targeted explorative ... -
Heavy metal threats to plants and soil life in Southern Africa: present knowledge and consequences for ecological risk assessment
(Springer, 2019)In recent times there has been remarkable development in the field of soil ecotoxicology and risk assessment (RA) models. It is, however, debatable if these RA models are robust representatives for worldwide relevance. In ... -
Lipidomic response to coffee consumption.
(MDPI, 2018)Coffee is widely consumed and contains many bioactive compounds, any of which may impact pathways related to disease development. Our objective was to identify individual lipid changes in response to coffee drinking. We ...