Browsing Research Output by Author "Carradori, Simone"
Now showing items 1-7 of 7
-
4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis
Secci, Daniela; Petzer, Anél; Petzer, Jacobus P.; Carradori, Simone; Guglielmi, Paulo (Taylor & Francis, 2019)A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted ... -
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents
Carradori, Simone; Petzer, Anél; Petzer, Jacobus P.; Ortuso, Francesco; Bagetta, Donatella (Elsevier, 2018)New 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives are proposed as dual-target-directed monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE) inhibitors, as well as antioxidant agents, for the treatment of ... -
Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors
Chimenti, Paola; Petzer, Anél; Petzer, Jacobus P.; Carradori, Simone; D’Ascenzio, Melissa (Elsevier, 2013)A series of 4-substituted-2-thiazolylhydrazone derivatives have been synthesized and tested in vitro for their human monoamine oxidase (hMAO) A and B inhibitory activity. Our findings confirmed that the substitution at ... -
Inhibition of human monoamine oxidase: biological and molecular modeling studies on selected natural flavonoids
Carradori, Simone; Petzer, Anél; Petzer, Jacobus P.; Gidaro, Maria Concetta; Costa, Giosuè (ACS, 2016)Naturally occurring flavonoids display a plethora of different biological activities, but emerging evidence suggests that this class of compounds may also act as antidepressant agents endowed with multiple mechanisms of ... -
Kaempferol as selective human MAO‑A inhibitor: analytical detection in Calabrian red wines, biological and molecular modeling studies
Gidaro, Maria Concetta; Petzer, Anél; Petzer, Jacobus P.; Astorino, Christian; Carradori, Simone (ACS, 2016)The purpose of this work was to determine the kaempferol content in three red wines of Calabria, a southern Italian region with a great number of certified food products. Considering that wine cultivar, climate, and soil ... -
MAO inhibitors and their wider applications: a patent review
Carradori, Simone; Petzer, Jacques P.; Secci, Daniela (Taylor & Francis, 2018)Introduction: Monoamine oxidase (MAO) inhibitors, after the initial ‘golden age’, are currently used as third-line antidepressants (selective MAO-A inhibitors) or clinically enrolled as co-adjuvants for neurodegenerative ... -
New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies
De Monte, Celeste; Petzer, Anél; N'Da, Clarina I.; Petzer, Jacobus P.; Carradori, Simone (Elsevier, 2014)Although there are clinical trials and in vivo studies in literature regarding the anxiolytic and antidepressant activities of the components of Crocus sativus L., their effects on the human monoamine oxidases (hMAO-A ...