Browsing Research Output by Author "Chibale, Kelly"

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    • Anticancer properties of distinct antimalarial drug classes 

      Hooft van Huijsduijnen, Rob; Haynes, Richard K.; Chibale, Kelly; Peitz, Ingmar; Kelter, Gerhard (PLoS, 2013)
      We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a panel of 91 human cancer lines. Three classes of drugs: artemisinins, synthetic peroxides and ...

    • Carbon‐14 radiolabeling and tissue distribution evaluation of MMV390048 

      Sonopo, Molahlehi S.; Zeevaart, Jan R.; Pillay, Adushan; Chibale, Kelly; Marjanovic-Painter, Biljana (Wiley, 2016)
      The antimalarial compound MMV390048 ([14C]-11) was labeled with carbon-14 isotope via a 3-step synthesis. It was obtained in a 15.5% radiochemical overall yield from carbon-14 labeled methyl iodide with a radiochemical ...