Browsing Research Output by Subject "Chitosan"
Now showing items 1-7 of 7
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Development and evaluation of a double-phase multiple-unit dosage form for enhanced insulin intestinal delivery
(Bentham Science, 2018)Background: The oral route is the most preferred route of administration for selfmedication, but poor membrane permeability and pre-systemic degradation are key challenges that need to be addressed. Objective: The purpose ... -
Direct compression of chitosan: process and formulation factors to improve powder flow and tablet performance
(Bentham Science, 2013)Chitosan is a polymer derived from chitin that is widely available at relatively low cost, but due to compression challenges it has limited application for the production of direct compression tablets. The aim of this study ... -
Intestinal drug absorption enhancers: synergistic effects of combinations
(Taylor & Francis, 2008)Although many absorption enhancers have been investigated, very few are used clinically. A need exists therefore for more effective absorption enhancers. The drug-absorption-enhancing effects of combinations of N-trimethyl ... -
Moulded cross-linked chitosan matrix systems for controlled drug release
(Taylor & Francis, 2011)Matrix-type drug delivery systems were prepared by moulding and drying cross-linked chitosan gels in 24-well plates and they were evaluated in terms of their physical properties, drug content, surface morphology and swelling. ... -
Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride
(Taylor & Francis, 2010)The aim of this study was to evaluate the ability of TMC, with different degrees of quaternization, to increase insulin absorption in vivo following nasal and rectal administration in rats. Two batches of TMC with different ... -
Novel highly-swellable and pH-responsive slow release formulations of clotrimazole with chitosan-g-PEG/starch microparticles
(Elsevier, 2019)Slow drug release from swellable matrices has attracted attention among researchers due to its target-specificity and the economics of slow release strategy. For this purpose, we synthesized chitosan (CS) and modified same ... -
Paracellular drug absorption enhancement through tight junction modulation
(Taylor & Francis, 2013)Introduction: Inclusion of absorption-enhancing agents in dosage forms is one approach to improve the bioavailability of active pharmaceutical ingredients with low membrane permeability. Tight junctions are dynamic protein ...