Browsing Research Output by Subject "DNA methylation"
Now showing items 1-9 of 9
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Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene
(Oxford Univ Press, 2015)Background: Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant effects remain unknown. While research using NaB has ... -
Assessing the DNA methylation status of single cells with the comet assay
(Elsevier, 2010)The comet assay (single cell gel electrophoresis) is a cost-effective, sensitive, and simple technique that is traditionally used for analyzing and quantifying DNA damage in individual cells. The aim of this study was to ... -
DNA methylation associated with mitochondrial dysfunction in a south african autism spectrum disorder cohort
(Wiley, 2020)Autism spectrum disorder (ASD) is characterized by phenotypic heterogeneity and a complex genetic architecture which includes distinctive epigenetic patterns. We report differential DNA methylation patterns associated with ... -
Exposure to high levels of fumarate and succinate leads to apoptotic cytotoxicity and altered global DNA methylation profiles in vitro
(Elsevier, 2017)In the Krebs cycle, succinate is oxidized to fumarate by succinate dehydrogenase (SDH), followed by the conversion of fumarate to malate by fumarate hydratase (FH). In cells with defective SDH and FH, the Krebs cycle is ... -
Investigating the effects of the presence of foreign DNA on DNA methylation and DNA repair events in cultured eukaryotic cells
(Elsevier, 2013)Methylation of DNA in eukaryotic cells, global as well as gene-specific, is affected by endogenous and endogenous factors. In this paper, it is reported that deviations in DNA methylation and expression of genes involved ... -
Is the role of circulating DNA as a biomarker of cancer being prematurely overrated?
(Elsevier, 2010)Background Circulating DNA is utilized widely as a genetic biomarker in a variety of pathological conditions, mainly in cancerous conditions. Quantification of circulating DNA and identifying the frequencies of a variety ... -
Levels of DNA methylation and transcript accumulation in leaves of transgenic maize varieties
(Springer, 2016)Background: Prior to their release in the environment, transgenic crops are examined for their health and environ‑ mental safety. In addition, transgene expression needs to be consistent in order to express the introduced ... -
Leveraging the urban-rural divide for epigenetic research
(Future Medicine, 2020)Urbanization coincides with a complex change in environmental exposure and a rapid increase in noncommunicable diseases (NCDs). Epigenetics, including DNA methylation (DNAm), is thought to mediate part of the association ... -
One year exposure to Cd- and Pb-contaminated soil causes metal accumulation and alteration of global DNA methylation in rats
(Elsevier, 2019)Metal pollution has been associated with anthropogenic activities, such as effluents and emissions from mines. Soil could be exposure route of wild rats to metals, especially in mining areas. The aim of this study was to ...