Browsing Research Output by Author "Erasmus, Elardus"
Now showing items 1-10 of 10
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Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge
Erasmus, Elardus; Van Reenen, Mari; Vorster, B. Chris; Reinecke, Carolus J.; Steffens, Francois E. (Public Library of Science, 2019)Chronic fatigue, in its various manifestations, frequently co-occur with pain, sleep disturbances and depression and is a non-communicable condition which is rapidly becoming endemic worldwide. However, it is handicapped ... -
Conservation of the coding regions of the glycine N-acyltransferase gene further suggests that glycine conjugation is an essential detoxification pathway
Van der Sluis, Rencia; Badenhorst, Christoffel P.S.; Erasmus, Elardus; Van Dyk, Etresia; Van der Westhuizen, Francois H.; Van Dijk, Alberdina A. (Elsevier, 2015)Thorough investigation of the glycine conjugation pathway has been neglected. No defect of the glycine conjugation pathway has been reported and this could reflect the essential role of glycine conjugation in hepatic ... -
Data on the optimisation of a solid phase extraction method for fractionating estrogen metabolites from small urine volumes
Van der Berg, Carien L.; Venter, Gerda; Van der Westhuizen, Francois H.; Erasmus, Elardus (Elsevier, 2020)Certain estrogen metabolites have been implicated in the pathophysiology of breast cancer. Moreover, the estrogen metabolite profiles of healthy women and those with (a high risk of) breast cancer differ significantly. The ... -
Development and validation of LC-ESI-MS/MS methods for quantification of 27 free and conjugated estrogen-related metabolites
Van der Berg, Carien; Venter, Gerda; Van der Westhuizen, Francois H.; Erasmus, Elardus (Elsevier, 2020)An imbalance in the estrogen metabolism has been associated with an increased risk of breast cancer development. Evaluation of the estrogen biotransformation capacity requires monitoring of various estrogen metabolites. ... -
Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation
Badenhorst, Christoffel Petrus Stephanus; Erasmus, Elardus; Van der Sluis, Rencia; Van Dijk, Alberdina Aike (Taylor & Francis, 2013)Introduction: Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C. 2.3.1.13), is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A ... -
In vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extract
Van der Westhuizen, Francois H.; Janse van Rensburg, Catharina S.; Rautenbach, George S.; Loots, Du Toit; Huysamen, Cristal; Louw, Roan; Pretorius, Pieter J.; Erasmus, Elardus; Marnewick, Jeanine L. (Wiley, 2008)The antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible cytotoxic, mutagenic/antimutagenic and genotoxic effects of RR ... -
L-Carnitine and long-chain acylcarnitines are positively correlated with ambulatory blood pressure in humans: the SABPA study
Mels, Catharina M. C.; Schutte, Aletta E.; Erasmus, Elardus; Huisman, Hugo W.; Schutte, Rudolph; Fourie, Carla M.T.; Kruger, Ruan; Van Rooyen, Johannes M.; Smith, Wayne; Malan, Nicolaas T.; Malan, Leoné (Springer, 2013)The prevalence of hypertension in sub-Saharan Africa is increasing rapidly, and treatment remains challenging. Although the use of l-carnitine in treatment has received much attention, studies reporting on physiological ... -
A laboratory approach for characterizing chronic fatigue: what does metabolomics tell us?
Erasmus, Elardus; Mason, Shayne; Van Reenen, Mari; Vorster, B. Chris; Reinecke, Carolus J. (Springer, 2019)Introduction Manifestations of fatigue range from chronic fatigue up to a severe syndrome and myalgic encephalomyelitis. Fatigue grossly affects the functional status and quality of life of affected individuals, prompting ... -
A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids
Badenhorst, Christoffel Petrus Stephanus; Erasmus, Elardus; Van der Sluis, Rencia; Nortje, Carla; Van Dijk, Alberdina Aike (Taylor & Francis, 2014)A number of endogenous and xenobiotic organic acids are conjugated to glycine, in animals ranging from mosquitoes to humans. Glycine conjugation has generally been assumed to be a detoxification mechanism, increasing the ... -
Unbalanced biotransformation metabolism and oxidative stress status: implications for deficient fatty acid oxidation
Mels, Catharina M.; Van der Westhuizen, Francois H.; Pretorius, Pieter J.; Erasmus, Elardus (Scientific Research, 2011)The concept of accumulating xenobiotics within the human body as a health risk is well known. However, these compounds can also be endo-genous, as in the case of inborn errors of me-tabolism, and lead to some of the same ...