Now showing items 1-18 of 18

    • Bioactive albumin-based carriers for tumour chemotherapy 

      Shahzad, Yasser; Gerber, Minja; Du Plessis, Jeanetta; Khan, Ikram U.; Hussain, Talib (Bentham Science, 2014)
      Proteins are posed as the natural counterpart of the synthetic polymers for the development of drug delivery systems and few of them, have been regarded safe for drug delivery purposes by the United States Food and Drug ...
    • Breaching the skin barrier through temperature modulations 

      Shahzad, Yasser; Louw, Ruaan; Gerber, Minja; Du Plessis, Jeanetta (Elsevier, 2015)
      The impermeability of the stratum corneum often hinders the transport of molecules across the skin. Temperature modulations in the skin and the application of local heat both have the potential of circumventing this problem ...
    • Essential fatty acids as transdermal penetration enhancers 

      Van Zyl, Lindi; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta; Viljoen, Joe (Elsevier, 2016)
      The aim of this study was to investigate the effect of different penetration enhancers, containing essential fatty acids (EFAs), on the transdermal delivery of flurbiprofen. Evening primrose oil (EPO), vitamin F and Pheroid™ ...
    • In vitro skin permeation of artemisone and its nano-vesicular formulations 

      Dwivedi, Anupma; Mazumder, Anisha; Fox, Lizelle T.; Brümmer, Alicia; Gerber, Minja; Du Preez, Jan L.; Haynes, Richard K.; Du Plessis, Jeanetta (Elsevier, 2016)
      The artemisinin derivative artemisone has antitumor activity. In particular when encapsulated in solid lipid nanoparticles (SLNs) and niosomes, it is active against human melanoma A-375 cells, although such formulations ...
    • In vivo skin hydration and anti-erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications 

      Fox, Lizelle T.; Du Plessis, Jeanetta; Gerber, Minja; Van Zyl, Sterna; Boneschans, Banie; Hamman, Josias H. (Medknow Publications, 2014)
      To investigate the skin hydrating and anti-erythema activity of gel materials from Aloe marlothii A. Berger and A. ferox Mill. in comparison to that of Aloe barbadensis Miller (Aloe vera) in healthy human volunteers. ...
    • Optimised transdermal delivery of pravastatin 

      Burger, Cornel; Gerber, Minja; Du Preez, Jan L.; Du Plessis, Jeanetta (Elsevier, 2015)
      Wiechers’ programme “Formulating for Efficacy” initiated a new strategy to optimise the oil phase of topical formulations in order to achieve optimal transdermal drug delivery. This new approach uses the “Delivery Gap ...
    • Penetration enhancing effects of selected natural oils utilized in topical dosage forms 

      Viljoen, Joe M.; Cowley, Amé; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta (Taylor & Francis, 2015)
      Context: Various natural products, including oils, have been utilized as penetration enhancers due to their “safety profiles”. These oils contain fatty acids promoting skin permeability through lipid fluidization within ...
    • Physical stability and clinical efficacy of Crocodylus niloticus oil lotion 

      Venter, Telanie; Fox, Lizelle Trifena; Gerber, Minja; Du Preez, Jan L.; Van Zyl, Sterna; Boneschans, Banie; Du Plessis, Jeanetta (Elsevier, 2016)
      The stability and the anti-ageing, skin hydrating and anti-erythema effects of a commercialized Crocodylus niloticus oil lotion was determined. The lotion was stored at controlled conditions over six months during which ...
    • Review of natural compounds for potential skin cancer treatment 

      Chinembiri, Tawona N.; Du Plessis, Lissinda H.; Gerber, Minja; Hamman, Josias H.; Du Plessis, Jeanetta (MDPI, 2014)
      Most anti-cancer drugs are derived from natural resources such as marine, microbial and botanical sources. Cutaneous malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. Various ...
    • Skin permeation enhancement effects of the gel and whole 1 leaf materials of A. vera, A. marlothii and A. ferox 

      Fox, Lizelle T.; Gerber, Minja; Du Preez, Jan L.; Du Plessis, Jeanetta; Hamman, Josias H. (Wiley, 2015)
      Objectives: The aim of this study was to investigate the in vitro permeation enhancement effects of the gel and whole leaf materials of Aloe vera, Aloe marlothii and Aloe ferox using ketoprofen as a marker compound. Methods: ...
    • Stability, clinical efficacy and antioxidant properties of honeybush extracts in semi-solid formulations. 

      Gerber, Gezina S.F.W.; Fox, Lizelle T.; Gerber, Minja; Du Preez, Jan L.; Van Zyl, Sterna; Boneschans, Banie; Du Plessis, Jeanetta (Medknow Publications, 2015)
      Background: Honeybush extracts (Cyclopia spp.) can be incorporated into skin care products to treat conditions such as skin dryness and can function as an anti-oxidant. Objective: To formulate Honeybush formulations and ...
    • Synthesis and transdermal penetration of stavudine-5'-esters. 

      Holmes, Estee-Marie; Breytenbach, Jaco C.; Gerber, Minja; Du Plessis, Jeanetta (Bentham Science, 2010)
      The aim of this study was to investigate the effects of different ester groups in position 5’ of stavudine on the transdermal penetration with and without the use of Pheroid™ as the delivery system. Six esters were prepared ...
    • Synthesis and transdermal properties of acetylsalicylic acid and selected esters 

      Gerber, Minja; Breytenbach, Jaco C.; Du Plessis, Jeanetta; Hadgraft, Jonathan (Elsevier, 2006)
      The primary aim of this study was to determine the transdermal penetration of acetylsalicylic acid and some of its derivatives, to establish a correlation, if any, with selected physicochemical properties and to determine ...
    • Topical delivery of 5-fluorouracil from Pheroid™ formulations and the in vitro efficacy against human melanoma 

      Chinembiri, Tawona N.; Gerber, Minja; Du Plessis, Lissinda; Du Preez, Jan; Du Plessis, Jeanetta (Springer, 2015)
      Drug delivery vehicles can influence the topical delivery and the efficacy of an active pharmaceutical ingredient (API). In this study the influence of Pheroid™ technology, which is a unique colloidal drug delivery system, ...
    • Topical delivery of acyclovir and ketoconazole 

      Jacobs, Gerda A.; Gerber, Minja; Malan, Maides M.; Du Preez, Jan L.; Fox, Lizelle T.; Du Plessis, Jeanetta (Taylor & Francis, 2014)
      Context: Viral and fungal cutaneous manifestations are regularly encountered in immunocompromised HIV/AIDS individuals and can be treated by drugs such as acyclovir and ketoconazole, respectively. Objective: The aim of ...
    • Transdermal drug delivery enhancement by compounds of natural origin 

      Fox, Lizelle T.; Gerber, Minja; Du Plessis, Jeanetta; Hamman, Josias H. (MDPI, 2011)
      The transdermal route of administration offers an alternative pathway for 20 systemic drug delivery with numerous advantages over conventional routes of 21 administration. Regrettably, the stratum corneum forms a formidable ...
    • Transdermal penetration of zalcitabine, lamivudine and synthesised N-acyl lamivudine ester 

      Gerber, Minja; Breytenbach, Jaco C.; Du Plessis, Jeanetta (Elsevier, 2008)
      The objective of this study was to determine the in vitro transdermal permeation through human epidermis of zalcitabine, lamivudine and the synthesised N-acyl lamivudine esters, with and without the use of Pheroid™ as ...
    • Vesicular carriers for skin drug delivery: the Pheroid™ technology 

      Kilian, Dewald; Shahzad, Yasser; Fox, Lizelle; Gerber, Minja; Du Plessis, Jeanetta (Bentham Science, 2015)
      The skin remains an attractive area for drug delivery. The skin, however, often limits the ingress of drugs, because of its very low permeability. Much research, focusing on employing a variety of physical and chemical ...