Browsing Research Output by Subject "Glycine N-acyltransferase"
Now showing items 1-4 of 4
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Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation
(Taylor & Francis, 2013)Introduction: Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C. 2.3.1.13), is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A ... -
New insights into the catalytic mechanism of human glycine N-acyltransferase
(Wiley, 2017)Even though the glycine conjugation pathway was one of the first metabolic pathways to be discovered, this pathway remains very poorly characterized. The bi-substrate kinetic parameters of a recombinant human glycine ... -
A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids
(Taylor & Francis, 2014)A number of endogenous and xenobiotic organic acids are conjugated to glycine, in animals ranging from mosquitoes to humans. Glycine conjugation has generally been assumed to be a detoxification mechanism, increasing the ... -
The use of p-aminobenzoic acid as a probe substance for the targeted profiling of glycine conjugation
(Wiley, 2016)Glycine conjugation facilitates the metabolism of toxic aromatic acids, capable of disrupting mitochondrial integrity. Owing to the high exposure to toxic substrates, characterization of individual glycine conjugation ...