Browsing Research Output by Subject "Isatin"

Boloka/Manakin Repository

Browsing Research Output by Subject "Isatin"

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  • Van der Walt, Elizna M.; Milczek, Erika M.; Malan, Sarel F.; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2009)
    Previous studies have shown that (E)-8-(3-chlorostyryl)caffeine (CSC) is a specific reversible inhibitor of human monoamine oxidase B (MAO-B) and does not bind to human MAO-A. Since the small molecule isatin is a natural ...
  • Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Manley-King, Clarina Ilara (Elsevier, 2011)
    Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced ...
  • Petzer, Jacobus Petrus; Petzer, Anél; Terre'Blanche, Gisella; Van der Walt, Mietha Magdalena (Elsevier, 2012)
    Monoamine oxidase (MAO) plays an essential role in the catabolism of neurotransmitter amines. The two isoforms of this enzyme, MAO-A and -B, are considered to be drug targets for the therapy of depression and neurodegenerative ...

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