Browsing Research Output by Subject "Lipid-based drug delivery system"
Now showing items 1-3 of 3
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Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria
(Wiley, 2014)Objectives Mefloquine (MQ) is an antimalarial drug with high efficacy, often used in the treatment and chemoprophylaxis of malaria. However, it has low solubility in water, a long elimination half-life (4 days), and is ... -
In vitro activity of Pheroid vesicles containing antibiotics against Plasmodium falciparum
(Springer Nature, 2012)The macrolide antibiotics, erythromycin and azithromycin, have been studied for their potential antimalarial activity, but only modest activity has been demonstrated. In this study, we investigated the enhancement of the ... -
In vivo efficacy and bioavailability of lumefantrine: evaluating the application of Pheroid technology
(Elsevier, 2015)The oral absorption of compounds with low aqueous solubility, such as lumefantrine, is typically limited by the dissolution rate in the gastro-intestinal tract, resulting in erratic absorption and highly variable ...