Browsing Research Output by Author "Möller, Marisa"
Now showing items 1-12 of 12
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Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort: the SABPA study
Möller, Marisa; Malan, Leoné; Mels, Carina M.C.; Malan, Nico T.; Magnusson, Martin (Wiley, 2017)Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative ... -
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma
Möller, Marisa; Du Preez, Jan L.; Harvey, Brian H. (Elsevier, 2012)It is highly beneficial to monitor the activity of the kynurenine pathway in a large series of samples with high accuracy and reliability in a single experimental protocol. We have developed a rapid specific solid-phase ... -
Efavirenz exposure, alone and in combination with known drugs of abuse, engenders addictive-like bio-behavioural changes in rats
Möller, Marisa; Fourie, Jaco; Harvey, Brian H. (Nature, 2018)Efavirenz is abused in a cannabis-containing mixture known as Nyaope. The addictive-like effects of efavirenz (5, 10 and 20 mg/kg) was explored using conditioned place preference (CPP) in rats following sub-acute exposure ... -
Garcinia mangostana Linn displays antidepressant-like and pro-cognitive effects in a genetic animal model of depression: a bio-behavioral study in the Flinders Sensitive Line rat
Oberholzer, Inge; Möller, Marisa; Harvey, Brian H.; Holland, Brendan; Dean, Olivia M. (Springer, 2018)There is abundant evidence for both disorganized redox balance and cognitive deficits in major depressive disorder (MDD). Garcinia mangostana Linn (GM) has anti-oxidant activity. We studied the antidepressant-like and ... -
Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration
Möller, Marisa; Du Preez, Jan L.; Harvey, Brian H.; Emsley, Robin (Elsevier, 2011)Social isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR ... -
N-acetyl cysteine reverses bio-behavioural changes induced by prenatal inflammation, adolescent methamphetamine exposure and combined challenges
Swanepoel, Twanette; Möller, Marisa; Harvey, Brian Herbert (Springer, 2018)Rationale Schizophrenia is associated with prenatal inflammation and/or postnatal stressors such as drug abuse, resulting in immune-redox dysfunction. Antioxidants may offer therapeutic benefits. Objectives The objective ... -
N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
Möller, Marisa; Du Preez, Jan L.; Viljoen, Francois P.; Harvey, Brian H.; Berk, Michael (Springer, 2013)Schizophrenia is causally associated with early-life environmental stress, implicating oxidative stress in its pathophysiology. N-acetyl cysteine (NAC), a glutathione precursor and antioxidant, is emerging as a useful ... -
A review of biomarkers in mood and psychotic disorders: a dissection of clinical vs. preclinical correlates
Brand, Sarel J.; Möller, Marisa; Harvey, Brian H. (Bentham Science, 2015)Despite significant research efforts aimed at understanding the neurobiological underpinnings of mood (depression, bipolar disorder) and psychotic disorders, the diagnosis and evaluation of treatment of these disorders are ... -
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment
Möller, Marisa; Du Preez, Jan L.; Harvey, Brian H.; Emsley, Robin (Elsevier, 2012)Schizophrenia is associated with increased oxidative stress, although the source of this redox disequilibrium requires further study. Altered tryptophan metabolism has been described in schizophrenia, possibly linked to ... -
Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
Möller, Marisa; Du Preez, Jan L.; Viljoen, Francois P.; Harvey, Brian H.; Berk, Michael; Emsley, Robin (Elsevier, 2013)Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and immune-inflammatory abnormalities, evidenced by oxidative stress, altered kynure nine metaboli sm and cytokine release . N-acetyl cysteine ... -
Studies into the anxiolytic actions of agomelatine in social isolation reared rats: role of corticosterone and sex
Regenass, Wilmie; Möller, Marisa; Harvey, Brian H. (Sage, 2018)Anxiety disorders are severely disabling, while current pharmacological treatments are complicated by delayed onset, low remission rates and side-effects. Sex is also noted to contribute towards illness severity and treatment ... -
Studies on haloperidol and adjunctive alpha-mangostin or raw Garcinia Mangostana Linn pericarp on bio-behavioral markers in an immune-inflammatory model of schizophrenia in male rats
Lotter, Jana; Möller, Marisa; Harvey, Brian H.; Dean, Olivia; Berk, Michael (Frontiers Media, 2020)The nematicidal activity of crudely milled powders of stems, leaves, and bulbs of Cassia abbreviata, Cissus cactiformis, Euphorbia ingens, Ipomoea kituiensis, Synadenium cupulare, Senna petersiana, Urigenia sanguinea, ...