Browsing Research Output by Author "Manley-King, Clarina I."
Now showing items 1-4 of 4
-
Inhibition of monoamine oxidase B by N-methyl-2-phenylmaleimides
Manley-King, Clarina I.; Terre'blanche, Gisella; Bergh, Jacobus J.; Petzer, Jacobus P.; Castagnoli, Neal (Elsevier, 2009)Based on a recent report that 1-methyl-3-phenylpyrrolyl analogues are moderately potent reversible inhibitors of the enzyme monoamine oxidase B (MAO-B), a series of structurally related N-methyl-2-phenylmaleimidyl analogues ... -
Inhibition of monoamine oxidase by C5-substituted phthalimide analogues
Manley-King, Clarina I.; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2011)Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced binding ... -
Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues
Manley-King, Clarina I.; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2011)Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding to the MAO-B isoform ... -
Monoamine oxidase inhibition by C4-substituted phthalonitriles
Manley-King, Clarina I.; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2012)It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B. Modeling studies suggested that the phthalimide ring forms ...