Browsing Research Output by Author "N’Da, David D."
Now showing items 1-3 of 3
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Antimalarial activity of 10-alkyl/aryl esters and – aminoethylethers of artemisinin
Cloete, Theunis T.; N’Da, David D.; Krebs, Henk J.; Clark, Julie A.; Connelly, Michele C. (Elsevier, 2013)A series of n-alkyl/aryl esters were synthesized and their in vitro antiplasmodial activity was measured alongside that of previously synthesized aminoethylethers of artemisinin ozonides against various strains of ... -
Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids
Lombard, Marli C.; N’Da, David D.; Van Ba, Christophe Tran; Wein, Sharon; Norman, Jennifer (BioMed Central, 2013)Background: Because Plasmodium falciparum displays increase tolerance against the recommended artemisinin combination therapies (ACT), new classes of anti-malarial drugs are urgently required. Previously synthesized ar ... -
Synthesis and antimalarial activity of ethylene glycol oligomeric ethers of artemisinin
Steyn, Minette; N’Da, David D.; Breytenbach, Jaco C.; Breytenbach, Wilma J.; Smith, Peter J. (Wiley, 2011)Objectives The aim of this study was to synthesize a series of ethylene glycol ether derivatives of the antimalarial drug artemisinin, determine their values for selected physicochemical properties and evaluate their ...