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Browsing Research Output by Author "Petzer, Anél"

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Browsing Research Output by Author "Petzer, Anél"

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  • Bergh, Jacobus Johannes; Mentz, Wayne; Mostert, Samantha; Petzer, Jacobus Petrus; Petzer, Anél (Elsevier, 2012)
    In a previous study we have investigated the monoamine oxidase (MAO) inhibitory properties of a series of 8-sulfanylcaffeine analogues. Among the compounds studied, 8-[(phenylethyl)sulfanyl]caffeine (IC50 = 0.223 lM) was ...
  • Bergh, Jacobus Johannes; Okaecwe, Thokozile Audrey Dorcas; Petzer, Jacobus Petrus; Swanepoel, Abraham Johannes; Petzer, Anél (Elsevier, 2012)
    A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives ...
  • Legoabe, Lesetja Jan; Petzer, Jacobus Petrus; Kruger, Johann; Petzer, Anél; Bergh, Jacobus J. (Elsevier, 2012)
    Chromone has been reported to be a useful scaffold for the design of monoamine oxidase (MAO) inhibitors. In an attempt to discover highly potent MAO inhibitors and to contribute to the known structureeactivity relationships ...
  • Bergh, Jacobus Johannes; Kruger, Johann; Legoabe, Lesetja Jan; Petzer, Jacobus Petrus; Petzer, Anél (Elsevier, 2011)
    A series of anilide derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The most potent inhibitors among the derivatives that were initially evaluated were ...
  • Petzer, Jacobus Petrus; Petzer, Anél; Terre'Blanche, Gisella; Van der Walt, Mietha Magdalena (Elsevier, 2012)
    Monoamine oxidase (MAO) plays an essential role in the catabolism of neurotransmitter amines. The two isoforms of this enzyme, MAO-A and -B, are considered to be drug targets for the therapy of depression and neurodegenerative ...
  • Legoabe, Lesetja Jan; Petzer, Jacobus Petrus; Petzer, Anél (Elsevier, 2012)
    A series of C7-substituted chromone (1-benzopyran-4-one) derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The chromones are structurally related to a series of ...
  • Legoabe, Lesetja Jan; Petzer, Jacobus Petrus; Petzer, Anél (Elsevier, 2012)
    A previous study has shown that a series of C6-benzyloxy substituted chromones exhibit high binding affinities for human monoamine oxidase (MAO) B. In an attempt to discover additional chromones with potent and selective ...
  • Lourens, Anna Catharina; Petzer, Jacobus Petrus; Van der Walt, Mietha Magdalena; Terre'Blanche, Gisella; Petzer, Anél (Elsevier, 2012)
    It has recently been reported that nitrile containing compounds frequently act as potent monoamine oxidase B (MAO-B) inhibitors. Modelling studies suggest that this high potency inhibition may rely, at least in part, on ...
  • Bergh, Jacobus Johannes; Booysen, Hermanus Perold; Moraal, Christina Maria; Petzer, Jacobus Petrus; Petzer, Anél; Terre'Blanche, Gisella (Elsevier, 2011)
    In a recent study it was shown that 8-benzyloxycaffeine analogues act as potent reversible inhibitors of human monoamine oxidase (MAO) A and B. Although the benzyloxy side chain appears to be particularly favorable for ...

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