Browsing Research Output by Subject "Pharmacokinetics"
Now showing items 1-8 of 8
-
All-atomistic molecular dynamics (AA-MD) studies and pharmacokinetic performance of PAMAM-dendrimer-furosemide delivery systems
(Elsevier, 2018)Improvement of problematic dissolution and solubility properties of a model drug, furosemide, was investigated for poly(amidoamine) (PAMAM) dendrimer complexes of the drug. Full and half generation dendrimers with amino ... -
Antimalarial and anticancer activities of artemisinin-quinoline hybrid-dimers and pharmacokinetic properties in mice
(Elsevier, 2012)Malaria, one of the three most important life-threatening infectious diseases, is recommended to be treated with ACT (artemisinin combination therapy) against which Plasmodium falciparum already displayed resistance. Two ... -
Combination therapy of western drugs and herbal medicines: recent advances in understanding interactions involving metabolism and efflux
(Taylor & Francis, 2012)Introduction: While complementary and alternative medicine markets prosper with an increasing number of consumers of herbal medicines, there is an associated likelihood for herb–drug interactions to occur. Modulation of ... -
The effect of the Pheroid delivery system on the in vitro metabolism and in vivo pharmacokinetics of artemisone
(Taylor & Francis, 2014)Objectives: The objectives were to determine the pharmacokinetics (PK) of artemisone and artemisone formulated in the Pheroid® drug delivery system in primates and to establish whether the formulation affects the in vitro ... -
Impact of traditional African medicine on drug metabolism and transport
(Taylor & Francis, 2014)Introduction: Africa is a continent of rich plant biodiversity with many indigenous plants having a long history of being used for medicinal purposes. A considerable number of patients consult traditional healers in ... -
In vitro efficacies, ADME, and pharmacokinetic properties of phenoxazine derivatives active against Mycobacterium tuberculosis
(ASM, 2019)Mycobacterium tuberculosis, the causative agent of tuberculosis, remains a leading infectious killer globally, demanding the urgent development of faster-acting drugs with novel mechanisms of action. Riminophenazines such ... -
In vitro oral drug permeation models: the importance of taking physiological and physico-chemical factors into consideration
(Taylor & Francis, 2016)Introduction: The assessment of intestinal membrane permeability properties of new chemical entities is a crucial step in the drug discovery and development process and a variety of in vitro models, methods and techniques ... -
Novel revelation of warfarin resistant mechanism in roof rats (Rattus rattus) using pharmacokinetic/pharmacodynamic analysis
(Elsevier, 2016)Roof rats (Rattus rattus) live mainly in human habitats. Heavy use of rodenticides, such as warfarin, has led to the development of drug resistance, making pest control difficult. There have been many reports regarding ...