Browsing Research Output by Author "Prins, Louis H.A."
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Crystal structure of a rearranged cage compound 3-hydroxy-4-aza-8-oxoheptacyclo [9.4.1.0-2,10-, 0 -3,14-, 0-4,9-, 0-9,13-, 0-12,12]tetradecane
Prins, Louis H.A.; De Vries, Armand; Oliver, Douglas W.; Van Dyk, Sandra; Malan, Sarel F. (Springer, 2008)Polycyclic hydrocarbon compounds exhibit a wide variety of biological activities, ranging from antiviral to Parkinson’s disease. Several structures such as the adamantanes have reached clinical status and are used ... -
Inhibition of monoamine oxidase by indole and benzofuran derivatives
Prins, Louis H.A.; Petzer, Jacobus P.; Malan, Sarel F. (Elsevier, 2010)Monoamine oxidase (MAO) is an important drug target for the treatment of neurological disorders. A series of indole and benzofuran derivatives were synthesised and evaluated as inhibitors of the two MAO isoforms, MAO-A and ... -
Multifunctional enzyme inhibition for neuroprotection: a focus on MAO, NOS, and AChE inhibitors
Joubert, Jacques; Petzer, Jacobus P.; Repsold, Benjamin P.; Prins, Louis H.A.; Malan, Sarel F. (Elsevier, 2015)Neurodegenerative disorders are known to be multifactorial in nature and current research focus has moved from a ‘one-drug-one-target approach’ to that of drugs which are able to act at various relevant biological targets. ... -
Synthesis and in vitro evaluation of pteridine analogues as monoamine oxidase B and nitric oxice synthase inhibitors
Prins, Louis H.A.; Petzer, Jacobus P.; Malan, Sarel F. (Elsevier, 2009)Monoamine oxidase B (MAO-B) and nitric oxide synthase (NOS) have both been implicated in the pathology of neurodegenerative diseases. In an attempt to design dual-target-directed drugs that inhibit both these enzymes, a ...