Browsing Research Output by Subject "Solubility"
Now showing items 1-7 of 7
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All-atomistic molecular dynamics (AA-MD) studies and pharmacokinetic performance of PAMAM-dendrimer-furosemide delivery systems
(Elsevier, 2018)Improvement of problematic dissolution and solubility properties of a model drug, furosemide, was investigated for poly(amidoamine) (PAMAM) dendrimer complexes of the drug. Full and half generation dendrimers with amino ... -
Amorphous azithromycin with improved aqueous solubility and intestinal membrane permeability
(Taylor & Francis, 2015)Azithromycin (AZM) is a poorly soluble macrolide antibacterial agent. Its low solubility is considered as the major contributing factor to its relatively low oral bioavailability. The aim of this study was to improve the ... -
Experimental and mesoscale computational dynamics studies of therelationship between solubility and release of quercetin from PEG solid dispersions
(Elsevier, 2013)The flavonol quercetin is potentially clinically relevant for its antimicrobial, beneficial cardiovasculareffects, cancer treatment amongst others. However, its successful therapeutic application is severelycurtailed by ... -
Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity
(Elsevier, 2013)Silver sulfadiazine (AgSD) is a topical antibiotic with limited aqueous solubility. In this study, it was shown that poly(amido amine) (PAMAM) dendrimer complexes with SD (SDZ) and silver (Ag) could be used for a bottom-up ... -
Poly(amidoamine) dendrimers as a pharmaceutical excipient. Are we there yet?
(Elsevier, 2018)Drug solubility could affect the therapeutic use of a drug because the biological activity of a drug is only possible if some fraction of a dissolved drug can permeate and overcome biological membranes to reach its site ... -
The role of functional excipients in solid oral dosage forms to overcome poor drug dissolution and bioavailability
(MDPI, 2020)Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The oral bioavailability of these compounds ... -
Role of novel drug delivery systems in bioavailability enhancement: at a glance
(DYR Labs, 2016)Novel drug delivery systems (NDDS) are one of the most strategies which enable to overcome the problems related to drug bioavailability. It is the rate and extent to which a drug becomes available to the target tissue after ...