Browsing Research Output by Author "Stein, Dan J."
Now showing items 1-13 of 13
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Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathology
Daniels, Willie M.U.; Savitz, Jonathan (Cambridge Univ Press, 2008)While monoaminergic hypotheses of psychopathology remain popular, there has been growing interest in the role of neurotrophins in neuropsychiatric disorders. Basic laboratory work has documented the importance of neurotrophins ... -
Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: attenuation after chronic fluoxetine treatment
Korff, Schaun; Harvey, Brian H.; Stein, Dan J. (Elsevier, 2009)Motor stereotypies, described as repetitive, topographically invariant and seemingly purposeless behaviours, are common to several developmental and neuropsychiatric disorders. While drug induced stereotypy has been ... -
Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse
Güldenpfennig, Marianne; Wolmarans, De Wet; Du Preez, Jan L.; Harvey, Brian H.; Stein, Dan J. (Elsevier, 2011)The deer mouse presents with spontaneous stereotypic movements that resemble the repetitive behaviours of obsessive–compulsive disorder (OCD), and demonstrates a selective response to serotonin reuptake inhibitors. OCD has ... -
Differential effects of social isolation rearing on glutamate- and GABA-stimulated noradrenaline release in the rat prefrontal cortex and hippocampus
Atmore, Katie H.; Harvey, Brian H.; Stein, Dan J.; Russell, Vivienne A.; Howells, Fleur M. (Elsevier, 2020)Social isolation rearing (SIR) provides an excellent model of early life adversity to investigate alterations in brain function. Few studies have investigated the effects of SIR on noradrenaline (NE) projections which arise ... -
Discovery versus implementation research on mental disorders in low- and middle-income countries. Editorial
Stein, Dan J.; Wegener, Gregers (Cambridge Univ Press, 2017)The 10/90 research gap refers to the fact that only 10% of the world’s research resources are spent in lowand middle-income countries (LMICs) although 90% of preventable deaths occur in these regions: similar disparities ... -
Excessive nest building is a unique behavioural phenotype in the deer mouse model of obsessive-compulsive disorder
Wolmarans, De Wet; Harvey, Brian H.; Stein, Dan J. (Sage, 2016)Obsessive–compulsive disorder (OCD) is a phenotypically heterogeneous condition characterised by time-consuming intrusive thoughts and/or compulsions. Irrespective of the symptom type diagnosed, the severity of OCD is ... -
Of mice and marbles: novel perspectives on burying behavior as a screening test for psychiatric illness
Wolmarans, De Wet; Harvey, Brian H.; Stein, Dan J. (Springer, 2016)Burying forms part of the normal behavioral routine of rodents, although its expression is species-specific. However, it has been suggested that aberrant burying behavior, of which marble-burying (MB) is an example, may ... -
Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges
Wolmarans, De Wet; Scheepers, Isabella M.; Harvey, Brian H.; Stein, Dan J. (Springer, 2018)Obsessive-compulsive disorder (OCD) is a prevalent and debilitating condition, characterized by intrusive thoughts and repetitive behavior. Animal models of OCD arguably have the potential to contribute to our understanding ... -
A psycho-behavioral perspective on modelling obsessive-compulsive disorder (OCD) in animals: the role of context
Wolmarans, De Wet; Stein, Dan J.; Harvey, Brian, H. (Bentham Science, 2017)Obsessive-compulsive disorder is a heterogeneous and debilitating condition, characterized by intrusive thoughts and compulsive repetition. Animal models of OCD are important tools that have the potential to contribute ... -
Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (OCD): response to chronic escitalopram treatment and basal serotonin transporter (SERT) density
Wolmarans, De Wet; Brand, Linda; Harvey, Brian H.; Stein, Dan J. (Elsevier, 2013)Obsessive-compulsive disorder (OCD) is characterized by recurrent thoughts and repetitive motor actions. Hyposerotonergic signalling in the cortico-striatal circuitry is believed to be central to the pathology of OCD, while ... -
Social behavior in deer mice as a novel interactive paradigm of relevance for obsessive-compulsive disorder (OCD)
Wolmarans, De Wet; Harvey, Brian H.; Stein, Dan J. (Taylor & Francis, 2017)Greater obsessive-compulsive (OC) symptom severity may be associated with poor social adjustment. Rather than possessing deficits in social skill per se, OCD patients may be more socially isolative in the presence of normal ... -
Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder
Korff, Schaun; Harvey, Brian H.; Stein, Dan J. (Elsevier, 2008)Stereotypy is an important manifestation of obsessive compulsive disorder (OCD). OCD involves disturbed serotonin and dopamine pathways, and demonstrates a selective response to serotonin reuptake inhibitors (SRI), with ... -
Stress and re-stress increases conditioned taste aversion learning in rats: possible frontal cortical and hippocampal muscarinic receptor involvement
Brand, Linda; Groenewald, Ilse; Harvey, Brian H.; Stein, Dan J.; Wegener, Gregers (Elsevier, 2008)Symptoms of posttraumatic stress disorder are often precipitated by sensory cues in the form of visual, auditory, olfactory and gustatory “flashbacks” resulting in enhanced fear-memory consolidation and the characteristic ...