Now showing items 1-7 of 7

    • 8-Aryl- and alkyloxycaffeine analogues as inhibitors of monoamine oxidase 

      Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Strydom, Belinda (Elsevier, 2011)
      Recently it was reported that a series of 8-benzyloxycaffeine analogues are potent reversible inhibitors of human monoamine oxidase (MAO) A and B. In an attempt to discover additional C8 oxy substituents of caffeine that ...
    • Dual-target-directed drugs that block monoamine oxidase B and adenosine A2A receptors for Parkinson’s disease 

      Petzer, Jacobus; Castagnoli, Neal; Schwarzschild, Michael A.; Chen, Jiang-Fan; Van der Schyf, J. (Springer, 2009)
      Inadequacies of the current pharmacotherapies to treat Parkinson’s disease (PD) have prompted efforts to identify novel drug targets. The adenosine A2A receptor is one such target. Antagonists of this receptor (A2A ...
    • The inhibition of monoamine oxidase by 8-(2-phenoxyethoxy) caffeine analogues 

      Strydom, Belinda; Bergh, Jacobus Johannes; Petzer, Jacobus Petrus (Thieme, 2012)
      Previous studies have documented that substituted 8-oxycaffeines act as inhibitors of human monoamine oxidase (MAO) B. A particularly potent inhibitor among the reported compounds was 8-(2-phenoxyethoxy)caffeine with an ...
    • Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues 

      Mostert, Samantha; Mentz, Wayne; Petzer, Anél; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2012)
      In a previous study we have investigated the monoamine oxidase (MAO) inhibitory properties of a series of 8-sulfanylcaffeine analogues. Among the compounds studied, 8-[(phenylethyl)sulfanyl]caffeine (IC50 = 0.223 lM) was ...
    • Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues 

      Strydom, Belinda; Malan, Sarel F.; Bergh, Jacobus J.; Petzer, Jacobus P.; Castagnoli, Neal (Elsevier, 2010)
      Based on recent reports that several (E)-8-styrylcaffeinyl analogues are potent reversible inhibitors of monoamine oxidase B (MAO-B), a series of 8-benzyloxycaffeinyl analogues were synthesized and evaluated as inhibitors ...
    • Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives 

      Okaecwe, Thokozile; Swanepoel, Abraham J.; Petzer, Anél; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2012)
      A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives ...
    • Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase 

      Bergh, Jacobus Johannes; Booysen, Hermanus Perold; Moraal, Christina Maria; Petzer, Jacobus Petrus; Petzer, Anél; Terre'Blanche, Gisella (Elsevier, 2011)
      In a recent study it was shown that 8-benzyloxycaffeine analogues act as potent reversible inhibitors of human monoamine oxidase (MAO) A and B. Although the benzyloxy side chain appears to be particularly favorable for ...