Now showing items 1-5 of 5

    • In vitro activity of Pheroid vesicles containing antibiotics against Plasmodium falciparum 

      Du Plessis, Lissinda H.; Van Niekerk, Anel C.; Maritz, Marlene M.; Kotzé, Awie F. (Nature Publishing Group, 2012)
      The macrolide antibiotics, erythromycin and azithromycin, have been studied for their potential antimalarial activity, but only modest activity has been demonstrated. In this study, we investigated the enhancement of the ...
    • Synthesis and antimalarial activity of ethylene glycol oligomeric ethers of artemisinin 

      Breytenbach, Jaco Cornelius; Meredith, Sandra; Smith, Peter; Steyn, Minette; N'Da, David Dago; Breytenbach, Wilhelmina Johanna (Wiley, 2011)
      Objectives The aim of this study was to synthesize a series of ethylene glycol ether derivatives of the antimalarial drug artemisinin, determine their values for selected physicochemical properties and evaluate their ...
    • Synthesis and antimalarial activity of ethylene glycol oligomeric ethers of artemisinin 

      Steyn, Minette; N’Da, David D.; Breytenbach, Jaco C.; Smith, Peter J.; Meredith, Sandra; Breytenbach, Wilma J. (Wiley, 2011)
      Objectives The aim of this study was to synthesize a series of ethylene glycol ether derivatives of the antimalarial drug artemisinin, determine their values for selected physicochemical properties and evaluate their ...
    • Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin 

      Breytenbach, Jaco Cornelius; Breytenbach, Johanna Wilhelmina; Cloete, Theunis Theodorus; N'da, David Dago; Smith, Peter; De Kock, Carmen (Elsevier, 2012)
      In this study, a series of 11 10-aminoethylether derivatives of artemisinin were synthesised and their antimalarial activity against both the chloroquine sensitive (D10) and resistant (Dd2) strains of Plasmodium falciparum ...
    • Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids 

      Breytenbach, Jaco Cornelius; Lombard, Martha Carolina; N'da, David Dago; Lategan, Carmen A.; Smith, Peter J. (Elsevier, 2011)
      Dihydroartemisinin (DHA) was coupled to different aminoquinoline moieties forming hybrids 9–14, which were then treated with oxalic acid to form oxalate salts (9a–14a). Compounds 9a, 10a, 12, 12a, and 14a showed comparable ...