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Inhibition of monoamine oxidase by phthalide analogues
(Elsevier, 2013)
Based on recent reports that the small molecules, isatin and phthalimide, are suitable scaffolds for the
design of high potency monoamine oxidase (MAO) inhibitors, the present study examines the MAO inhibitory
properties ...
Synthesis and evaluation of chromone derivatives as inhibitors of monoamine oxidase
(Springer, 2019)
Based on reports that chromone compounds are good potency inhibitors of monoamine oxidase (MAO), the present study evaluates the effect of substitution with flexible side chains on the 3 position on MAO inhibition potency. ...
Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles
(MDPI, 2019)
New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized
in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase
A and B. The most important chiral ...
4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis
(Taylor & Francis, 2019)
A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted ...
Evaluation of selected natural compounds as dual inhibitors of catechol-o-methyltransferase and monoamine oxidase
(Bentham Science, 2019)
Background: The most effective symptomatic treatment of Parkinson’s disease remains the metabolic precursor of dopamine, L-dopa. To enhance the efficacy of L-dopa, it is often combined with inhibitors of the enzymes, ...
Synthesis and evaluation of 2-benzylidene-1-tetralone derivatives for monoamine oxidase inhibitory activity
(Bentham Science, 2018)
Background: Chalcone has been identified as a promising lead for the design of Monoamine Oxidase (MAO) inhibitors. This study attempted to discover potent and selective chalcone-derived MAO inhibitors by synthesising a ...
Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase
(Elsevier, 2011)
In a recent study it was shown that 8-benzyloxycaffeine analogues act as potent reversible inhibitors of human monoamine oxidase (MAO) A and B. Although the benzyloxy side chain appears to be particularly favorable for ...
SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs
(Taylor & Francis, 2019)
The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. ...
Selected chromone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2012)
A previous study has shown that a series of C6-benzyloxy substituted chromones exhibit high binding affinities for human monoamine oxidase (MAO) B. In an attempt to discover additional chromones with potent and selective ...
Selected C7-substituted chromone derivatives as monoamine oxidase inhibitors
(Elsevier, 2012)
A series of C7-substituted chromone (1-benzopyran-4-one) derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The chromones are structurally related to a series of ...