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Exploring 4–substituted–2–thiazolylhydrazones from 2–, 3–, and 4–acetylpyridine as selective and reversible hMAO–B inhibitors
(ELSEVIER, 2013)
A series of 4-substituted-2-thiazolylhydrazone derivatives have been synthesized and tested in vitro for
their human monoamine oxidase (hMAO) A and B inhibitory activity. Our findings confirmed that the
substitution at ...
Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues
(Elsevier, 2010)
Based on recent reports that several (E)-8-styrylcaffeinyl analogues are potent reversible inhibitors of
monoamine oxidase B (MAO-B), a series of 8-benzyloxycaffeinyl analogues were synthesized and evaluated
as inhibitors ...
Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase
(Elsevier, 2011)
In a recent study it was shown that 8-benzyloxycaffeine analogues act as potent reversible inhibitors of human monoamine oxidase (MAO) A and B. Although the benzyloxy side chain appears to be particularly favorable for ...
The inhibition of monoamine oxidase by 8-(2-phenoxyethoxy) caffeine analogues
(Thieme, 2012)
Previous studies have documented that substituted 8-oxycaffeines act as inhibitors of human monoamine oxidase (MAO) B. A particularly potent inhibitor among the reported compounds was 8-(2-phenoxyethoxy)caffeine with an ...
Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues
(Elsevier, 2011)
Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding to the MAO-B isoform ...
Inhibition of monoamine oxidase by C5-substituted phthalimide analogues
(Elsevier, 2011)
Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors
of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced ...
8-Aryl- and alkyloxycaffeine analogues as inhibitors of monoamine oxidase
(Elsevier, 2011)
Recently it was reported that a series of 8-benzyloxycaffeine analogues are potent reversible inhibitors of human monoamine oxidase (MAO) A and B. In an attempt to discover additional C8 oxy substituents of caffeine that ...
Benzyloxynitrostyrene analogues: a novel class of selective and highly potent inhibitors of monoamine oxidase B
(Elsevier, 2017)
This study examines a series of novel 3-benzyloxy-β-nitrostyrene analogues as a novel class of inhibitors of the monoamine oxidase (MAO) enzymes. MAO inhibitors are considered useful for the treatment of depression and ...
The monoamine oxidase inhibition properties of selected structural analogues of methylene blue
(Elsevier, 2017)
The thionine dye, methylene blue (MB), is a potent inhibitor of monoamine oxidase (MAO) A, a property that may, at least in part, mediate its antidepressant effects in humans and animals. The central inhibition of MAO-A ...
The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase
(Elsevier, 2017)
The monoamine oxidase (MAO) enzymes are of considerable pharmacological interest and inhibitors are used in the clinic for the treatment of major depressive disorder and Parkinson's disease. A limited number of studies ...