Search
Now showing items 1-9 of 9
Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives
(Elsevier, 2014)
Malaria remains one of the world's most common infectious diseases, being responsible for more deaths than any other communicable disease except tuberculosis. There is strong evidence that tumour necrosis factor α and ...
Synthesis, in vitro antimalarial activity and cytotoxicity of novel 4-aminoquinolinyl-chalcone amides
(Elsevier, 2014)
A series of 4-aminoquinolinyl-chalcone amides 11–19 were synthesized through condensation of carboxylic
acid-functionalized chalcone with aminoquinolines, using 1,10-carbonyldiimidazole as coupling
agent. These compounds ...
Assessment of pregnancy status, malaria knowledge and malaria fever morbidity among women of reproductive ages in Nigeria
(Tehran University of Medical Sciences, 2014)
Malaria is one the major health problem in Nigeria. During pregnancy, it poses serious threat to the survival of both unborn foetus and the mothers. This study determined the effect of adequate malaria knowledge and pregnancy ...
Synthesis, in vitro antiplasmodial and antiproliferative activities of a series of quinoline-ferrocene hybrids
(Springer, 2014)
Series of quinoline–ferrocene hybrids containing
various linkers were synthesized and evaluated for
antimalarial and anticancer activities as well as cytotoxicity.
The hybrids with rigid linkers were found to be ...
Synthesis, in vitro antiplasmodial activity and cytotoxicity of a series of artemisininetriazine hybrids and hybrid-dimers
(Elsevier, 2014)
A series of artemisininetriazine hybrids and hybrid-dimers were synthesized and their in vitro antimalarial
activity against the chloroquine sensitive (CQS), the gametocytocidal (NF54) and the choroquine
resistant (CQR) ...
Synthesis and in vitro biological evaluation of aminoacridines and artemisinin-acridine hybrids
(Elsevier, 2014)
During this study, 9-aminoacridine and artemisinin–acridine hybrid compounds were synthesized and the in vitro for antimalarial activity against both the chloroquine sensitive but also gametocytocidal strain (NF54), and ...
Maternal factors influencing timeliness of seeking treatment for fever in children under five and healthcare preferences in Malawi
(2014)
Malaria is a critical health challenge in Malawi, especially among children under the age of five. This study analyzed the factors influencing timeliness of seeking malaria treatments and preferences among health care ...
Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria
(Wiley, 2014)
Objectives Mefloquine (MQ) is an antimalarial drug with high efficacy, often
used in the treatment and chemoprophylaxis of malaria. However, it has low solubility
in water, a long elimination half-life (4 days), and is ...
Trends in malaria admissions at the Mbakong Health Centre of the North West Region of Cameroon: a retrospective study
(BioMed Central, 2014)
Background: Malaria is the leading cause of death worldwide. It is urgent to assess the impact of interventions and
scaled-up control efforts. Despite reported reduction in malaria prevalence in Africa, the trends in ...