Search
Now showing items 41-50 of 58
Disclosure of a putative biosignature for respiratory chain disorders through a metabolomics approach
(Springer, 2013)
The diagnosis of respiratory chain deficiencies
(RCDs) is complicated and the need for a diagnostic biomarker
or biosignature has been widely expressed. In this
study, the metabolic profile of a selected group of 29 ...
Metabolomics of colistin methanesulfonate treated Mycobacterium tuberculosis
(Elsevier, 2018)
Over the past 5 years, there has been a renewed interest in finding new compounds with anti-TB action. Colistin methanesulfonate or polymyxin E, is a possible anti-TB drug candidate, which may in future be used either alone ...
Can a metabolomics-based approach be used as alternative to analyse fatty acid methyl esters from soil microbial communities?
(Elsevier, 2016)
Modern high-throughput approaches such as metabolomics, holds promise for investigating microbial communities. This study evaluated the quantitative and qualitative data generation potential of a metabolomics-based approach ...
Predicting tuberculosis treatment outcome using metabolomics
(Future Medicine, 2017)
Aim: Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and ...
Metabolomics of urinary organic acids in respiratory chain deficiencies in children
(Springer, 2012)
Metabolomic analysis of the urinary organic
acids from 39 selected children with defined respiratory
chain deficiencies (RCDs) was performed using untargeted
gas chromatography–mass spectrometry, revealing the
presence ...
A comparison of four sputum pre-extraction preparation methods for identifying and characterising Mycobacterium tuberculosis using GCxGC-TOFMS metabolomics
(Elsevier, 2012)
In many pulmonary diseases, sputum is a valuable sample material for use in disease characterisation and diagnostics. However, due to its high viscosity and uneven consistency (lumpiness), it is difficult to obtain ...
New sputum metabolite markers implicating adaptations of the host to Mycobacterium tuberculosis, and vice versa
(Elsevier, 2013)
In this study, a metabolomics research approach was used to identify new tuberculosis (TB) markers from
sputum, in an attempt to better characterise the disease as well as the metabolic response of the host to
Mycobacterium ...
Fetal metabolic stress disrupts immune homeostasis and induces proinflammatory responses in human immunodeficiency virus type 1- and combination antiretroviral therapy-exposed infants
(Oxford Univ Press, 2017)
Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological ...
Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test
(Nature, 2019)
The mitochondrial energy score (MES) protocol, developed by the Myhill group, is marketed as a diagnostic test for chronic fatigue syndrome/Myalgic Encephalomyelitis (CFS/ME). This study assessed the reliability and ...
Metabolomics of mitochondrial disease
(Elsevier, 2017)
Mitochondrial disease (MD) diagnostics and disease progression investigations have traditionally relied very little on metabolic data, due to a lack of biomarker sensitivity and specificity. The recent drive to find novel, ...