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Concurrent class analysis identifies discriminatory variables from metabolomics data on isovaleric acidemia
(Springer, 2012)
Metabolomics data are typically complex and high dimensional. Multivariate dimension-reducing techniques have thus been developed for analysing metabolomics data to disclose underlying relationships, with principal component ...
Metabolomics of Ndufs4−/− skeletal muscle: adaptive mechanisms converge at the ubiquinone-cycle
(Elsevier, 2019)
Leigh syndrome is one of the most common childhood-onset neurometabolic disorders resulting from a primary oxidative phosphorylation dysfunction and affecting mostly brain tissues. Ndufs4−/− mice have been widely used to ...
Novel insights into the pharmacometabonomics of first-line tuberculosis drugs relating to metabolism, mechanism of action and drug-resistance
(Taylor & Francis, 2018)
The World Health Organization recommends the directly observed therapy short-course (DOTS) regimen, a combination of four first-line antibiotics (isoniazid, rifampicin, pyrazinamide and ethambutol), for the treatment of ...
Quantitative metabolomics of a xylose-utilizing Saccharomyces cerevisiae strain expressing the Bacteroides thetaiotaomicron xylose isomerase on glucose and xylose
(Springer, 2017)
The yeast Saccharomyces cerevisiae cannot utilize xylose, but the introduction of a xylose isomerase that functions well in yeast will help overcome the limitations of the fungal oxido-reductive pathway. In this study, a ...
The altered human serum metabolome induced by a marathon
(Springer, 2018)
Introduction
Endurance races have been associated with a substantial amount of adverse effects which could lead to chronic disease and long-term performance impairment. However, little is known about the holistic metabolic ...
Total metabolome extraction from mycobacterial cells for GC-MS metabolomics analysis
(Humana, 2019)
Over the past 10 years, the number of metabolomics based publications in the available scientific literature has exponentially grown, a large portion of which describing new biomarkers better elucidating microbial disease ...
Abalone growth and associated aspects: now from a metabolic perspective
(Wiley, 2018)
Worldwide, there are approximately 100 Haliotis species, more commonly known as abalone or ‘Paua’ in New Zealand, ‘Venus's‐ears’ in Greece, ‘Awabi’ in Japan, ‘Perlemoen’ in South Africa and ‘Ormers’ in Europe. Regardless ...
A comparison of two extraction methods for differentiating and characterising various Mycobacterium species and Pseudomonas aeruginosa using GC-MS metabolomics
(Academic Journals, 2012)
We investigated the capacity of a metabolomics research approach to characterise and differentiate between various infectious Mycobacterium species and Pseudomonas aeruginosa, and compared two extraction procedures; 1) ...
A metabolomics approach to characterise and identify various Mycobacterium species
(Elsevier, 2012)
We investigated the potential use of gas chromatography mass spectrometry (GC–MS), in combination with multivariate statistical data processing, to build a model for the classification of various tuberculosis (TB) causing, ...
A metabolomics approach exploring the function of the ESX-3 type VII secretion system of M. smegmatis
(Springer, 2013)
The genome of Mycobacterium, including
Mycobacterium tuberculosis, contains five copies of a
cluster of genes encoding a novel type VII secretion system,
named the ESX gene cluster region. This ESX-3 gene
cluster is ...