Browsing Faculty of Health Sciences by Author "b1eade56-1541-4119-8a29-ed319b3acb49"
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Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease
Joubert, Jacques; Repsold, Benjamin P.; Oliver, Douglas W.; Foka, Germaine B.; Kapp, Erika; Malan, Sarel F. (Elsevier, 2017)A series of 7-substituted coumarin derivatives were designed and synthesised to display ChE and MAO-B inhibitory activity. The compounds consisted out of a coumarin structure (MAO-B inhibitor) and benzyl-, piperidine-, ...