Browsing Faculty of Health Sciences by Title
Now showing items 1140-1159 of 2386
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In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells
(Elsevier, 2015)Artemisone is a 10-amino-artemisinin derivative that is markedly superior in vitro and in vivo to current artemisinins against malaria and also possesses antitumor activity. In seeking to capitalise on the last property, ... -
In vitro anti-trypanosomal activities of indanone-based chalcones
(Thieme, 2019)Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine ... -
In vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extract
(Wiley, 2008)The antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible cytotoxic, mutagenic/antimutagenic and genotoxic effects of RR ... -
In vitro determination of the preclinical safety of Pheroid® doxorubicin formulations using patch clamp assays
(Elsevier, 2019)One of the most active, widely used and well-known drugs in breast cancer chemotherapy, doxorubicin (DOX), is an anthracycline ring antibiotic derived from the bacteria Streptomyces peucetius. Its clinical use is however, ... -
In vitro drug absorption enhancement effects of Aloe vera and Aloe ferox
(Österreichische Apotheker-Verlagsgesellschaft, 2012)The effect of whole leaf and gel materials from two aloe species (Aloe vera and A. ferox) was compared with that of the precipitated polysaccharides from these aloe materials on the transepithelial electrical resistance ... -
In vitro drug permeation enhancement potential of aloe gel materials
(Bentham Science, 2012)Aloe vera gel previously showed the ability to increase the bioavailability of vitamins and to enhance the in vitro transport of a macromolecular drug across intestinal epithelial cell monolayers. The purpose of this study ... -
In vitro efficacies, ADME, and pharmacokinetic properties of phenoxazine derivatives active against Mycobacterium tuberculosis
(ASM, 2019)Mycobacterium tuberculosis, the causative agent of tuberculosis, remains a leading infectious killer globally, demanding the urgent development of faster-acting drugs with novel mechanisms of action. Riminophenazines such ... -
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes
(Elsevier, 2020)Leishmaniasis is a neglected tropical disease affecting thousands worldwide, especially in developing countries where it co-exists with malaria. Only a handful of drugs are clinically available to treat the disease, but ... -
In vitro evaluation of the cytotoxic and apoptogenic properties of aloe whole leaf and gel materials
(Taylor & Francis, 2014)Aloe gel and whole-leaf materials have shown biological effects with potential therapeutic applications, and recently, their drug-absorption enhancement properties have been discovered. It is important to establish a ... -
In vitro oral drug permeation models: the importance of taking physiological and physico-chemical factors into consideration
(Taylor & Francis, 2016)Introduction: The assessment of intestinal membrane permeability properties of new chemical entities is a crucial step in the drug discovery and development process and a variety of in vitro models, methods and techniques ... -
In vitro permeation of mesembrine alkaloids from Sceletium tortuosum across porcine buccal, sublingual, and intestinal mucosa
(Thieme, 2012)Sceletium tortuosum is an indigenous South African plant that has traditionally been used for its mood-enhancing properties. Recently, products containing S. tortuosum have become increasingly popular and are commonly ... -
In vitro permeation of metals through human skin: a review and recommendations
(American Chemical Society, 2015)During the last few decades, the interest in skin permeation of, specifically, metals has increased with the in vitro method utilizing diffusion cells as the prominent method of investigating permeability. This review ... -
In vitro permeation of platinum and rhodium through Caucasian skin
(Elsevier, 2014)During platinum group metals (PGMs) refining the possibility exists for dermal exposure to PGM salts. The dermal route has been questioned as an alternative route of exposure that could contribute to employee sensitisation, ... -
In vitro permeation of platinum through African and Caucasian skin
(Elsevier, 2015)The majority of the South African workforce are Africans, therefore potential racial differences should be considered in risk and exposure assessments in the workplace. Literature suggests African skin to be a superior ... -
In vitro skin permeation of artemisone and its nano-vesicular formulations
(Elsevier, 2016)The artemisinin derivative artemisone has antitumor activity. In particular when encapsulated in solid lipid nanoparticles (SLNs) and niosomes, it is active against human melanoma A-375 cells, although such formulations ... -
In vitro skin permeation of sinigrin from its phytosome complex
(Wiley, 2016)Objectives: Sinigrin is a major glucosinolate present in plants of the Brassicaceae family. Recently sinigrin and its phytosome formulations have been investigated for its wound healing actions, by our research group. The ... -
In vitro wound healing and cytotoxic activity of the gel and whole-leaf materials from selected aloe species
(Elsevier, 2017)Ethnopharmacological relevance Aloe vera is one of the most important medicinal plants in the world with applications in the cosmetic industry and also in the tonic or health drink product market. Different parts of Aloe ... -
In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex
(Elsevier, 2016)Sinigrin is a class of glucosinolates found naturally in plants of the Brassicaceae family. Lately, studies have shown that sinigrin possesses anticancer, antibacterial and anti-inflammatory activities. Since its efficacy ... -
In vivo efficacy and bioavailability of lumefantrine: evaluating the application of Pheroid technology
(Elsevier, 2015)The oral absorption of compounds with low aqueous solubility, such as lumefantrine, is typically limited by the dissolution rate in the gastro-intestinal tract, resulting in erratic absorption and highly variable ... -
In vivo evaluation of acute intravenous toxicity of a [Ga-68]Ga-PSMA-11-microemulsion
(Elsevier, 2020)Microemulsions (MEs) are reported to improve the efficacy of a drug, minimise side effects and toxicity of the encapsulated compound. MEs are hypothesized to aid in making the encapsulated compound, which has been incorporated ...