Browsing Faculty of Health Sciences by Title
Now showing items 1154-1173 of 2386
-
In vitro skin permeation of artemisone and its nano-vesicular formulations
(Elsevier, 2016)The artemisinin derivative artemisone has antitumor activity. In particular when encapsulated in solid lipid nanoparticles (SLNs) and niosomes, it is active against human melanoma A-375 cells, although such formulations ... -
In vitro skin permeation of sinigrin from its phytosome complex
(Wiley, 2016)Objectives: Sinigrin is a major glucosinolate present in plants of the Brassicaceae family. Recently sinigrin and its phytosome formulations have been investigated for its wound healing actions, by our research group. The ... -
In vitro wound healing and cytotoxic activity of the gel and whole-leaf materials from selected aloe species
(Elsevier, 2017)Ethnopharmacological relevance Aloe vera is one of the most important medicinal plants in the world with applications in the cosmetic industry and also in the tonic or health drink product market. Different parts of Aloe ... -
In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex
(Elsevier, 2016)Sinigrin is a class of glucosinolates found naturally in plants of the Brassicaceae family. Lately, studies have shown that sinigrin possesses anticancer, antibacterial and anti-inflammatory activities. Since its efficacy ... -
In vivo efficacy and bioavailability of lumefantrine: evaluating the application of Pheroid technology
(Elsevier, 2015)The oral absorption of compounds with low aqueous solubility, such as lumefantrine, is typically limited by the dissolution rate in the gastro-intestinal tract, resulting in erratic absorption and highly variable ... -
In vivo evaluation of acute intravenous toxicity of a [Ga-68]Ga-PSMA-11-microemulsion
(Elsevier, 2020)Microemulsions (MEs) are reported to improve the efficacy of a drug, minimise side effects and toxicity of the encapsulated compound. MEs are hypothesized to aid in making the encapsulated compound, which has been incorporated ... -
In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems
(Elsevier, 2010)The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the possible toxic effects of these particles have raised some ... -
In vivo skin hydration and anti-erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications
(Medknow, 2014)To investigate the skin hydrating and anti-erythema activity of gel materials from Aloe marlothii A. Berger and A. ferox Mill. in comparison to that of Aloe barbadensis Miller (Aloe vera) in healthy human volunteers. ... -
In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles
(Elsevier, 2010)Nanoparticulate drug delivery systems offer great promise in addressing challenges of drug toxicity, poor bioavailability and non-specificity for a number of drugs. Much progress has been reported for nano drug delivery ... -
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid
(Elsevier, 2013)Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small ... -
In-vitro cytotoxicity of various Siphonochilus aethiopicus (Schweinf.) B.L. Burtt extracts in combination with selected tableting excipients
(Wiley, 2019)Objectives To investigate the cytotoxic potential of S. aethiopicus extracts in combination with chitosan and Pharmacel 101, on two cell lines. Methods Extracts were chemically characterised utilising UPLC-Q-TOF/MS, ... -
In-vitro transdermal penetration of cytarabine and its N4-alkylamide derivatives
(Wiley, 2010)Objectives The aim of this study was to synthesise and determine the transdermal penetration of cytarabine alkylamide derivatives and assess the correlation of flux with physicochemical properties. Methods The alkylamide ... -
Inactivation of Anopheles gambiae Glutathione Transferase ε2 by Epiphyllocoumarin
(Hindawi Publishing Corporation, 2016)Glutathione transferases (GSTs) are part of a major family of detoxifying enzymes that can catalyze the reductive dehydrochlorination of dichlorodiphenyltrichloroethane (DDT). The delta and epsilon classes of insect GSTs ... -
Inappropriate medicine prescribing in older South Africans: a cross-sectional analysis of medicine claims data
(Health & Medical Publishing Group, 2016)Background. Prescribing for older patients is a well-recognised problem, and inappropriate items are prescribed frequently. Several tools and criteria are available to promote rational prescribing in older patients. Objective. ... -
Incorporating orange-fleshed sweet potato into the food system as a strategy for improved nutrition: the context of South Africa
(Elsevier, 2018)Orange-fleshed sweet potato (OFSP) is considered the single most successful example of biofortification of a staple crop, and presents a feasible option to address vitamin A deficiency. Though initially promoted as part ... -
Increased stress-evoked nitric oxide signaling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression
(Oxford Univ Press, 2010)Stress engenders the precipitation and progression of affective disorders, while stress-related release of excitatory mediators is implicated in the degenerative pathology observed especially in the hippocampus of patients ... -
Increasing access to drug utilization data globally: developing an action plan
(Wiley, 2018)Background: Drug utilization (DU) research intends to support health authorities in the development of evidence‐informed pharmaceutical policy and practice guidelines, with the interest of the patients and communities in ... -
Increasing coping and strengthening resilience in nurses providing mental health care: empirical qualitative research
(AOSIS, 2018)Background: Research on coping and resilience is on the rise. However, there is a paucity of information addressing strengths, assets, competence or resilience that enable nurses to remain committed and cope in their ... -
Indanones as high-potency reversible inhibitors of monoamine oxidase
(Wiley, 2015)Recent reports document that α-tetralone (3,4-dihydro-2H-naphthalen-1-one) is an appropriate scaffold for the design of high-potency monoamine oxidase (MAO) inhibitors. Based on the structural similarity between α-tetralone ... -
Indigenous and traditional plants: South African parents’ knowledge, perceptions and uses and their children’s sensory acceptance
(BioMed Central, 2013)Background: The dietary shift from indigenous and traditional plants (ITPs) to cash crops and exotic plant food sources increases the risk of malnutrition and other nutrition-related non-communicable diseases, especially ...