Browsing Faculty of Health Sciences by Title
Now showing items 1162-1181 of 2385
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In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid
(Elsevier, 2013)Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small ... -
In-vitro cytotoxicity of various Siphonochilus aethiopicus (Schweinf.) B.L. Burtt extracts in combination with selected tableting excipients
(Wiley, 2019)Objectives To investigate the cytotoxic potential of S. aethiopicus extracts in combination with chitosan and Pharmacel 101, on two cell lines. Methods Extracts were chemically characterised utilising UPLC-Q-TOF/MS, ... -
In-vitro transdermal penetration of cytarabine and its N4-alkylamide derivatives
(Wiley, 2010)Objectives The aim of this study was to synthesise and determine the transdermal penetration of cytarabine alkylamide derivatives and assess the correlation of flux with physicochemical properties. Methods The alkylamide ... -
Inactivation of Anopheles gambiae Glutathione Transferase ε2 by Epiphyllocoumarin
(Hindawi Publishing Corporation, 2016)Glutathione transferases (GSTs) are part of a major family of detoxifying enzymes that can catalyze the reductive dehydrochlorination of dichlorodiphenyltrichloroethane (DDT). The delta and epsilon classes of insect GSTs ... -
Inappropriate medicine prescribing in older South Africans: a cross-sectional analysis of medicine claims data
(Health & Medical Publishing Group, 2016)Background. Prescribing for older patients is a well-recognised problem, and inappropriate items are prescribed frequently. Several tools and criteria are available to promote rational prescribing in older patients. Objective. ... -
Incorporating orange-fleshed sweet potato into the food system as a strategy for improved nutrition: the context of South Africa
(Elsevier, 2018)Orange-fleshed sweet potato (OFSP) is considered the single most successful example of biofortification of a staple crop, and presents a feasible option to address vitamin A deficiency. Though initially promoted as part ... -
Increased stress-evoked nitric oxide signaling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression
(Oxford Univ Press, 2010)Stress engenders the precipitation and progression of affective disorders, while stress-related release of excitatory mediators is implicated in the degenerative pathology observed especially in the hippocampus of patients ... -
Increasing access to drug utilization data globally: developing an action plan
(Wiley, 2018)Background: Drug utilization (DU) research intends to support health authorities in the development of evidence‐informed pharmaceutical policy and practice guidelines, with the interest of the patients and communities in ... -
Increasing coping and strengthening resilience in nurses providing mental health care: empirical qualitative research
(AOSIS, 2018)Background: Research on coping and resilience is on the rise. However, there is a paucity of information addressing strengths, assets, competence or resilience that enable nurses to remain committed and cope in their ... -
Indanones as high-potency reversible inhibitors of monoamine oxidase
(Wiley, 2015)Recent reports document that α-tetralone (3,4-dihydro-2H-naphthalen-1-one) is an appropriate scaffold for the design of high-potency monoamine oxidase (MAO) inhibitors. Based on the structural similarity between α-tetralone ... -
Indigenous and traditional plants: South African parents’ knowledge, perceptions and uses and their children’s sensory acceptance
(BioMed Central, 2013)Background: The dietary shift from indigenous and traditional plants (ITPs) to cash crops and exotic plant food sources increases the risk of malnutrition and other nutrition-related non-communicable diseases, especially ... -
Indigenous knowledge, food production and food security in rural Khambashe in the Eastern Cape, South Africa
(Taylor & Francis, 2019)In the then Ciskei, the apartheid policy of separate development introduced a decentralised industrialisation system. This strategy promoted the establishment of firms and factories in the Bantustans and Homelands (i.e., ... -
Indigenous practices regarding postnatal care at Sikhunyani village in the Limpopo Province of South Africa
(Department Health Studies, University of South Africa, 2009)In South Africa women are discharged from maternity wards 24 hours after normal deliveries. The result is that postnatal care is provided by family members and grandmothers who are often assisted by traditional birth ... -
Indirect implications of COVID-19 prevention strategies on non-communicable diseases: an opinion paper of the European Society of Hypertension Working Group on Hypertension and Cardiovascular Risk Assessment in subjects living in or emigrating from low resource settings
(BMC, 2020)Background After its outbreak in China, the novel COronaVIrus Disease 19 is spreading across the globe. It is an emergency the world has never seen before. Main text The attention of health systems is mainly focused ... -
Inequalities in the use of secondary prevention of cardiovascular disease by socioeconomic status: evidence from the PURE observational study
(Elsevier, 2018)Background There is little evidence on the use of secondary prevention medicines for cardiovascular disease by socioeconomic groups in countries at different levels of economic development. Methods We assessed use of ... -
Infant development at the age of 6 months in relation to feeding practices, iron status, and growth in a peri-urban community of South Africa
(MDPI, 2018)Background: Evidence on the association between feeding practices, iron deficiency, anaemia, stunting, and impaired psychomotor development during infancy is limited. This study assessed the association between psychomotor ... -
Inflammation and salt in young adults: the African-PREDICT study
(Springer, 2020)Purpose Low-grade inflammation and a diet high in salt are both established risk factors for cardiovascular disease. High potassium (K+) intake was found to counter increase in blood pressure due to high salt intake and ... -
Inflammation as possible mediator for the relationship between lung and artirial function
(Springer, 2016)Introduction Reduced lung function is associated with a risk for the development of cardiovascular disease. This association may be due to chronic inflammation which is often present in those with reduced lung ... -
The influence of a diversion programme on the psycho-social functioning of youth in conflict with the law in the Northwest Province
(CRIMSA, 2011)Diversion is a process of channelling children away from the formal court system to programmes that are re-integrative. A child can be diverted when he / she acknowledges responsibility for the act and both he / she and ... -
The influence of an unplanned caesarean section on initial mother-infant bonding: mothers' subjective experiences
(Taylor & Francis, 2013)This study explored the impact of an unplanned Caesarean section on mother-infant bonding, by examining the development of maternal identities and mothers’ subsequent relationships with their babies. In-depth interviews ...