Browsing Faculty of Health Sciences by Title
Now showing items 120-139 of 2386
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Antimalarial N-1,N-3-dialkyldioxonaphthoimidazoliums: synthesis, biological activity, and structure-activity relationships
(ACS, 2020)Here we report the nanomolar potencies of N1,N3-dialkyldioxonaphthoimidazoliums against asexual forms of sensitive and resistant Plasmodium falciparum. Activity was dependent on the presence of the fused quinone-imidazolium ... -
Antimicrobial activity and in vitro cytotoxicity of selected South African Helichrysum species
(Elsevier, 2011)The antimicrobial activity of 35 indigenous South African Helichrysum species was determined against six microorganisms. Seven of the 36 chloroform:methanol (1:1) extracts (leaf and stem extracts for all plants and an ... -
The antimicrobial peptide nisin Z induces selective toxicity and apoptotic cell death in cultured melanoma cells
(Elsevier, 2018)Reprogramming of cellular metabolism is now considered one of the hallmarks of cancer. Most malignant cells Reprogramming of cellular metabolism is now considered one of the hallmarks of cancer. Most malignant cells present ... -
Antimicrobial peptides: the Achilles’ heel of antibiotic resistance?
(Springer, 2018)Antibiotic resistance is an imminent threat to the effective treatment of bacterial infections, and alternative antibiotic strategies are urgently required. The golden epoch of antibiotics is coming to an end, and the ... -
Antioxidant enzyme activity is associated with blood pressure and carotid intima media thickness in black men and women: the SABPA study
(Elsevier, 2016)In the urbanized black population of South Africa, oxidative stress may play a crucial role in the development of hypertension. Since oxidative stress may result from impaired antioxidant capacity we aimed to investigate ... -
Antioxidant properties of 4-quinolones and structurally related flavones
(Elsevier, 2012)Neurodegenerative disorders are frequently associated with increased oxidative damage to the brain as a result of free radicals produced by cellular respiration. The onset and progression of neurodegeneration may therefore ... -
The antioxidant properties, cytotoxicity and monoamine oxidase inhibition abilities of the crude dichloromethane extract of Tarchonanthus camphoratus L. leaves
(Academic Journals, 2011)Tarchonanthus camphoratus (camphor bush) has been widely used for numerous medicinal purposes. The aim of the present study was to evaluate the antioxidant properties, cytotoxicity and monoamine oxidase inhibition activities ... -
Antiplasmodial activity and cytotoxicity of 10β-aminoquinolinylethylethers of artemisinin
(Thieme, 2013)Each year roughly 800 000 people die of malaria, with 95% being African children. The shortcomings of the current drugs and the emergence of P. falciparum resistance to the artemisinin class of compounds warrant the search ... -
Antiretroviral prescriptions with potential drug-drug interactions from general practitioners and specialists
(Health and Medical Publishing Group, 2011) -
Antirheumatic medicine prescribing patterns and direct medicine costs in the South African private health sector
(Elsevier, 2018)Objectives To describe antirheumatic medicine prescribing patterns and to estimate the total annual direct medicine cost of rheumatoid arthritis (RA) in the private health sector of South Africa. Methods A retrospective, ... -
Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies
(Springer, 2008)The phosphodiesterase (PDE) 5 inhibitor sildenafil has been shown to display psychotropic actions in humans and animals, and has been used for the treatment of antidepressant-associated erectile dysfunction. However, its ... -
The application of pharmacoeconomic modelling to estimate a value-based price for new cancer drugs
(Wiley, 2010)Rationale, aims and objectives Value‐based pricing has recently been discussed by international bodies as a means to estimate a drug price that is linked to the benefits it offers patients and society. The World Health ... -
Applications of lipid based formulation technologies in the delivery of biotechnology-based therapeutics
(Bentham Science, 2014)In the last decades several new biotechnologically-based therapeutics have been developed due to progress in genetic engineering. A growing challenge facing pharmaceutical scientists is formulating these compounds into ... -
Applying a transdisciplinary mixed methods research design to explore sustainable diets in rural South Africa
(Sage, 2015)This article describes a conceptual framework for exploring sustainable diets, using a case study example of ongoing research in the Vaalharts region, a rural setting in South Africa. A qualitative research approach is ... -
Applying mixed-methods to assess the value of forensic interviewing from a person-centred approach
(CRIMSA, 2011)Diversion is a process of channelling children away from the formal court system to programmes that are re-integrative. A child can be diverted when he / she acknowledges responsibility for the act and both he / she and ... -
Appraisal of ozone as biologically active molecule and experimental tool in biomedical sciences
(Springer, 2011)Ozone (O3) (CAS 10028-15-6) is a major air industrial pollutant and is well known for its very strong oxidative actions which affords the molecule its useful antimicrobial and deodorizing properties, but also its potential ... -
Appropriate and non-medical use of methylphenidate by residence students at a South African tertiary institution
(LAM Publications, 2017)The purpose was to determine to what degree residence students from a tertiary academic institution use methylphenidate in both non-medical and appropr iate manners in the South African ... -
Approximation-based integral versus differential isoconversional approaches to the evaluation of kinetic parameters from thermogravimetry: kinetic analysis of the dehydration of a pharmaceutical hydrate
(Springer, 2016)The relative accuracies of approximation-based integral versus differential isoconversional approaches for ‘actual’ E determination were investigated on experimental dehydration data of roxithromycin monohydrate ... -
Are antiretroviral prescribed according to the recommended prescribed daily doses in the private healthcare sector in South Africa
(AOSIS, 2011)Current antiretroviral treatment (ART) guidelines recommend different combinations that have led to major improvements in the management of HIV and AIDS in the developed and developing world. With the rapid approval of ... -
Are behavioural risk factors to be blamed for the conversion from optimal blood pressure to hypertensive status in black South Africans? A 5-year prospective study
(Oxford University Press, 2012)Background Longitudinal cohort studies in sub-Saharan Africa are urgently needed to understand cardiovascular disease development. We, therefore, explored health behaviours and conventional risk factors of African individuals ...