Browsing Faculty of Health Sciences by Title
Now showing items 1438-1457 of 2386
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Mind your state: insights into antidepressant nonadherence
(MedPharm Publications, 2016)Major depressive disorder (MDD) is an insidious disease and affects up to 15% of the global population. Although MDD responds to a wide range of pharmacological treatment options, a number of factors, i.e. not adhering ... -
Missing data imputation via the expectation-maximization algorithm can improve principal component analysis aimed at deriving biomarker profiles and dietary patterns
(Elsevier, 2020)Principal component analysis (PCA) is a popular statistical tool. However, despite numerous advantages, the good practice of imputing missing data before PCA is not common. In the present work, we evaluated the hypothesis ... -
Mitochondria are critical for BDNF-mediated synaptic and vascular plasticity of hippocampus following repeated electroconvulsive seizures
(Oxford Univ Press, 2018)Background Electroconvulsive therapy is a fast-acting and efficient treatment of depression used in the clinic. The underlying mechanism of its therapeutic effect is still unclear. However, recovery of synaptic connections ... -
Mitochondrial DNA replication and OXPHOS gene transcription show varied responsiveness to Rieske protein knockdown in 143B cells
(Elsevier, 2011)Genetic, biochemical and phenotypic diversity is a hallmark of OXPHOS deficiencies. Among the responses frequently reported for these deficiencies is differential expression of several genes involved in mitochondrial ... -
Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment
(Wiley, 2013)Depressive disorders and the treatment thereof have been associated with a number of neuroplastic events, such as neurogenesis and synaptic remodeling in discrete areas of the brain. The associations of these events in ... -
A mixed methods approach to adapting and evaluating the functional assessment of HIV infection (FAHI), Swahili version, for use with low literacy populations
(Public Library of Science, 2017)Background Despite bearing the largest HIV-related burden, little is known of the Health-Related Quality of Life (HRQoL) among people living with HIV in sub-Saharan Africa. One of the factors contributing to this gap in ... -
The Mmogo-method: discovering symbolic community interactions
(Elliott & Fitzpatrick, 2008) -
A model for a positive youth development intervention
(Taylor & Francis, 2012)Modern-day life necessitates the application of interventions to facilitate the development of the youth in a more positive trajectory. Lacunae in the Positive Youth Development (PYD) paradigm include, inter alia, the ... -
A Model for incorporating specialist nurse education into a University context. Part 1: Methodological perspectives
(OpenJournals Publishing, 2010) -
Model for the education of neonatal nurses as reflective practitioners
(University of the Free State & Sun Media, 2009)A model is developed for the education of neonatal nurses as reflective practitioners in a South African context to prepare them for their demanding role in neonatal nursing practice. An exploratory and descriptive design ... -
A model for the incorporation of the traditional healers into the national health care delivery system of South Africa System of South Africa
(African networks on ethnomedicines, 2012)In South Africa the patient uses both the traditional healers and biomedical personnel’s services out of need for the best healing therapy to fulfil his/ her health needs. Failure of one to yield the expected results leads ... -
A model of isoniazid treatment of tuberculosis
(Elsevier, 2014)A mathematical model is presented of the growth and death of bacilli in a granuloma. The granuloma is treated with isoniazid (INH), a drug that inhibits the synthesis of mycolic acids (MA). Since MA is an essential component ... -
Modeling nanoparticle delivery of TB drugs to granulomas
(Elsevier, 2016)Tuberculosis, which typically presents as a pulmonary disease, has a complex pathology. The primary site of infection, the Ghon focus, recruits immune cells and a granuloma forms. At earlier stages the granuloma is still ... -
Models used to screen for the treatment of multidrug resistant cancer facilitated by transporter-based efflux
(Springer, 2019)Purpose Efflux transporters of the adenosine triphosphate-binding cassette (ABC)-superfamily play an important role in the development of multidrug resistance (multidrug resistant; MDR) in cancer. The overexpression of ... -
Modern contraceptive use among reproductive-aged women in Ghana: prevalence, predictors, and policy implications
(BioMed Central, 2018)Background: Modern contraceptive use remains an important public health intervention and a cost-effective strategy to reduce maternal mortality, avert unintended pregnancies and to control population explosion, especially in ... -
Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study
(Elsevier, 2020)Background Global estimates of the effect of common modifiable risk factors on cardiovascular disease and mortality are largely based on data from separate studies, using different methodologies. The Prospective Urban ... -
Modulation of drug efflux by aloe materials: an in vitro investigation across rat intestinal tissue
(Medknow, 2013)Background: Clinically, significant herb-drug interactions have been previously documented and can be pharmacodynamic and/or pharmacokinetic in nature. Pharmacokinetic interactions have been attributed to induction or ... -
A molecular analysis of the GBA gene in Caucasian South Africans with Parkinson's disease
(Wiley, 2017)Background The molecular basis of Parkinson's disease in South African population groups remains elusive. To date, substitutions in the GBA gene are the most common large-effect genetic risk factor for Parkinson's disease. ... -
Molecular imaging of a zirconium-89 labeled antibody targeting Plasmodium falciparum–infected human erythrocytes
(Springer, 2020)Purpose Nuclear imaging is an important preclinical research tool to study infectious diseases in vivo and could be extended to investigate complex aspects of malaria infections. As such, we report for the first time ... -
Molecular phylogeny of the southern African endemic genus Sisyranthus (Apocynaceae: Asclepiadoideae-Ceropegieae)
(Elsevier, 2017)Sisyranthus E.Mey. species are placed in the tribe Ceropegieae, subtribe Anisotominae (Apocynaceae-Asclepiadoideae). Plants have their fertile parts hidden in the tube of the flowers, and are cryptic in both their habit ...