Browsing Faculty of Health Sciences by Title
Now showing items 1450-1469 of 2385
-
Models used to screen for the treatment of multidrug resistant cancer facilitated by transporter-based efflux
(Springer, 2019)Purpose Efflux transporters of the adenosine triphosphate-binding cassette (ABC)-superfamily play an important role in the development of multidrug resistance (multidrug resistant; MDR) in cancer. The overexpression of ... -
Modern contraceptive use among reproductive-aged women in Ghana: prevalence, predictors, and policy implications
(BioMed Central, 2018)Background: Modern contraceptive use remains an important public health intervention and a cost-effective strategy to reduce maternal mortality, avert unintended pregnancies and to control population explosion, especially in ... -
Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study
(Elsevier, 2020)Background Global estimates of the effect of common modifiable risk factors on cardiovascular disease and mortality are largely based on data from separate studies, using different methodologies. The Prospective Urban ... -
Modulation of drug efflux by aloe materials: an in vitro investigation across rat intestinal tissue
(Medknow, 2013)Background: Clinically, significant herb-drug interactions have been previously documented and can be pharmacodynamic and/or pharmacokinetic in nature. Pharmacokinetic interactions have been attributed to induction or ... -
A molecular analysis of the GBA gene in Caucasian South Africans with Parkinson's disease
(Wiley, 2017)Background The molecular basis of Parkinson's disease in South African population groups remains elusive. To date, substitutions in the GBA gene are the most common large-effect genetic risk factor for Parkinson's disease. ... -
Molecular imaging of a zirconium-89 labeled antibody targeting Plasmodium falciparum–infected human erythrocytes
(Springer, 2020)Purpose Nuclear imaging is an important preclinical research tool to study infectious diseases in vivo and could be extended to investigate complex aspects of malaria infections. As such, we report for the first time ... -
Molecular phylogeny of the southern African endemic genus Sisyranthus (Apocynaceae: Asclepiadoideae-Ceropegieae)
(Elsevier, 2017)Sisyranthus E.Mey. species are placed in the tribe Ceropegieae, subtribe Anisotominae (Apocynaceae-Asclepiadoideae). Plants have their fertile parts hidden in the tube of the flowers, and are cryptic in both their habit ... -
Monitoring physical activity after a cardiovascular event: what is ‘fit’ for purpose?
(Sage, 2018)n the September issue of European Journal of Preventive Cardiology, Lavie and colleagues discussed how physical activity across the lifespan is a cost-effective strategy that must be implemented globally to improve overall ... -
Monitoring the South African population’s salt intake: spot urine v. 24 h urine
(Cambridge Univ Press, 2018)Objective The present study set out to determine whether morning spot urine samples can be used to monitor Na (and K) intake levels in South Africa, instead of the ‘gold standard’ 24 h urine sample. Design Participants ... -
Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma
(Thieme, 2011)The aim of this study was to synthesize a series of mono-, di- and trisubstituted derivatives of the human African trypanosomiasis drug eflornithine (alpha-difluoromethylornithine, DMFO, CAS 70052-12-9) to determine their ... -
Monoamine oxidase inhibition by C4-substituted phthalonitriles
(Elsevier, 2012)It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B. Modeling studies suggested that the phthalimide ring forms ... -
Monoamine oxidase inhibition by Kavalactones from Kava (Piper Methysticum)
(Thieme, 2019)Monoamine oxidases (MAOs) are key metabolic enzymes for neurotransmitter and dietary amines and are targets for the treatment of neuropsychiatric and neurodegenerative disorders. This study examined the MAO inhibition ... -
Monoamine oxidase inhibition by selected anilide derivatives
(Elsevier, 2011)A series of anilide derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The most potent inhibitors among the derivatives that were initially evaluated were ... -
Monoamine oxidase inhibition by selected dye compounds
(Wiley, 2019)Monoamine oxidase (MAO) is an important drug target as the MAO isoforms play key roles in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as in neuropsychiatric diseases such as ... -
The monoamine oxidase inhibition properties of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one derivatives
(Springer, 2020)Quinazolinone compounds are of interest in medicinal chemistry since they display a wide range of biological properties. In the present study, a series of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one ... -
The monoamine oxidase inhibition properties of C6-mono- and N3/C6-disubstituted derivatives of 4(3H)-quinazolinone
(Elsevier, 2019)Parkinson’s disease is characterised by the death of the nigrostriatal neurons and depletion of striatal dopamine. The standard symptomatic therapy consists of dopamine replacement with l-dopa, the metabolic precursor of ... -
The monoamine oxidase inhibition properties of selected structural analogues of methylene blue
(Elsevier, 2017)The thionine dye, methylene blue (MB), is a potent inhibitor of monoamine oxidase (MAO) A, a property that may, at least in part, mediate its antidepressant effects in humans and animals. The central inhibition of MAO-A ... -
Monoamine oxidase inhibitory activities of heterocyclic chalcones
(Elsevier, 2015)Studies have shown that natural and synthetic chalcones (1,3-diphenyl-2-propen-1-ones) possess monoamine oxidase (MAO) inhibition activities. Of particular importance to the present study is a report that a series of ... -
More good news about polymeric plant- and algae-derived biomaterials in drug delivery systems
(Bentham Science, 2014)Natural polymers are continuously investigated for use in pharmaceutical and tissue engineering applications due to the renewability of their supply. Besides the conventional use of natural materials in dosage form design ... -
Morning blood pressure surge in young black and white adults: the African-PREDICT study. Correction to this article: Journal of human hypertension (2019) 33:172. https://doi.org/10.1038/s41371-018-0121-7
(Nature, 2019)An exaggerated morning blood pressure surge (MBPS) has independent predictive value for cardiovascular mortality and is suggested to be prevalent in elderly hypertensive patients: men and white populations. To better ...