Browsing Faculty of Health Sciences by Title
Now showing items 1459-1478 of 2385
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Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma
(Thieme, 2011)The aim of this study was to synthesize a series of mono-, di- and trisubstituted derivatives of the human African trypanosomiasis drug eflornithine (alpha-difluoromethylornithine, DMFO, CAS 70052-12-9) to determine their ... -
Monoamine oxidase inhibition by C4-substituted phthalonitriles
(Elsevier, 2012)It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B. Modeling studies suggested that the phthalimide ring forms ... -
Monoamine oxidase inhibition by Kavalactones from Kava (Piper Methysticum)
(Thieme, 2019)Monoamine oxidases (MAOs) are key metabolic enzymes for neurotransmitter and dietary amines and are targets for the treatment of neuropsychiatric and neurodegenerative disorders. This study examined the MAO inhibition ... -
Monoamine oxidase inhibition by selected anilide derivatives
(Elsevier, 2011)A series of anilide derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The most potent inhibitors among the derivatives that were initially evaluated were ... -
Monoamine oxidase inhibition by selected dye compounds
(Wiley, 2019)Monoamine oxidase (MAO) is an important drug target as the MAO isoforms play key roles in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as in neuropsychiatric diseases such as ... -
The monoamine oxidase inhibition properties of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one derivatives
(Springer, 2020)Quinazolinone compounds are of interest in medicinal chemistry since they display a wide range of biological properties. In the present study, a series of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one ... -
The monoamine oxidase inhibition properties of C6-mono- and N3/C6-disubstituted derivatives of 4(3H)-quinazolinone
(Elsevier, 2019)Parkinson’s disease is characterised by the death of the nigrostriatal neurons and depletion of striatal dopamine. The standard symptomatic therapy consists of dopamine replacement with l-dopa, the metabolic precursor of ... -
The monoamine oxidase inhibition properties of selected structural analogues of methylene blue
(Elsevier, 2017)The thionine dye, methylene blue (MB), is a potent inhibitor of monoamine oxidase (MAO) A, a property that may, at least in part, mediate its antidepressant effects in humans and animals. The central inhibition of MAO-A ... -
Monoamine oxidase inhibitory activities of heterocyclic chalcones
(Elsevier, 2015)Studies have shown that natural and synthetic chalcones (1,3-diphenyl-2-propen-1-ones) possess monoamine oxidase (MAO) inhibition activities. Of particular importance to the present study is a report that a series of ... -
More good news about polymeric plant- and algae-derived biomaterials in drug delivery systems
(Bentham Science, 2014)Natural polymers are continuously investigated for use in pharmaceutical and tissue engineering applications due to the renewability of their supply. Besides the conventional use of natural materials in dosage form design ... -
Morning blood pressure surge in young black and white adults: the African-PREDICT study. Correction to this article: Journal of human hypertension (2019) 33:172. https://doi.org/10.1038/s41371-018-0121-7
(Nature, 2019)An exaggerated morning blood pressure surge (MBPS) has independent predictive value for cardiovascular mortality and is suggested to be prevalent in elderly hypertensive patients: men and white populations. To better ... -
Morning blood pressure surge relates to autonomic neural activity in young non-dipping adults: the African-PREDICT study
(Elsevier, 2019)Background It is well established that an exaggerated morning blood pressure surge (MBPS) is associated with an increased risk for cardiovascular disease development in hypertensive individuals. However, in non-dipping ... -
Morpho‐functional characteristics of bone marrow multipotent Mesenchymal Stromal Cells after activation or inhibition of epidermal growth factor and toll‐like receptors or treatment with DNA intercalator cisplatin
(Wiley, 2019)This study is aimed to reveal morphological and functional changes in multipotent mesenchymal stromal cells (MSCs) isolated from the rat bone marrow after: (i) activation of Toll‐like receptors (TLRs) with teichoic acid ... -
Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV1 (PURE): an international, community-based cohort study
(Elsevier, 2019)Background The associations between the extent of forced expiratory volume in 1 s (FEV1) impairment and mortality, incident cardiovascular disease, and respiratory hospitalisations are unclear, and how these associations ... -
Mortality and morbidity in relation to changes in albuminuria, glucose status and systolic blood pressure: an analysis of the ONTARGET and TRANSCEND studies
(Springer Verlag (Germany), 2014)Aims/hypothesis Urinary albumin excretion is a strong predictor of cardiovascular disease. It is uncertain whether improvement from microalbuminuria or deterioration from normoalbuminuria over time in patients with differing ... -
Motivations for relationships as sources of meaning: Ghanaian and South African experiences
(Frontiers Media, 2020)Afrocentric paradigms reflect assumptions of the overarching importance of interconnectedness and social bonds in meaningful experiences. It is, however, not known if types of relatedness vary in importance as meaning ... -
The motor development of 2 to 6-year old children infected with HIV
(The Southern African Alliance for Sport Science, Physical Education and Recreation., 2008) -
Motor proficiency profile of grade 1 learners In the North West Province of South Africa: NW-child study
(University of Stellenbosch Department of Sport Science, 2014)This study aimed to establish a comprehensive profile of the motor proficiency of Grade 1 learners in the North West Province of South Africa, taking into account gender and racial differences and strengths and weaknesses. ... -
Moulded cross-linked chitosan matrix systems for controlled drug release
(Taylor & Francis, 2011)Matrix-type drug delivery systems were prepared by moulding and drying cross-linked chitosan gels in 24-well plates and they were evaluated in terms of their physical properties, drug content, surface morphology and swelling. ... -
Multi-media for flipped classrooms: engaged nutrition learning in a multi-media enhanced flipped classroom
(Unisa, 2015)This article focuses on the experiences of Health Science students changing from a traditional lecturer–centred, face–to–face teaching scenario to a multi–modal learning experience in a flipped classroom. Getting students ...