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Browsing Faculty of Health Sciences@PUK by Title

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Browsing Faculty of Health Sciences@PUK by Title

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  • Franken, Anja; Eloff, Frederik; Du Plessis, Johannes; Van Aarde, Michiel; Laubscher, Petrus (Mine Ventiliation Society of South Africa, 2009)
    Noise-induced hearing loss (NIHL) in the South African mining industry can be prevented, but only by incorporating more proactive and innovative measures into NIHL prevention programmes. At present, direct and indirect ...
  • Van Aardt, Annette Marie; Van Staden, Johanna (Wiley-Blackwell, 2011)
    Fashion information is sought during the fashion decision-making process and can be obtained from various sources such as magazines, fashion consultants, websites and store displays. Various levels and methods such as ...
  • Magenta, Daniele; Sangiovanni, Enrico; Basilico, Nicoletta; Haynes, Richard, K.; Parapini, Silvia (Elsevier, 2014)
    Malaria remains one of the world's most common infectious diseases, being responsible for more deaths than any other communicable disease except tuberculosis. There is strong evidence that tumour necrosis factor α and ...
  • Magenta, Daniele; Haynes, Richard K.; Sangiovanni, Enrico; Basilico, Nicoletta; Parapini, Silvia (Elsevier, 2014)
    Malaria remains one of the world's most common infectious diseases, being responsible for more deaths than any other communicable disease except tuberculosis. There is strong evidence that tumour necrosis factor α and ...
  • Manley-king, Clarina Ilara; Terre'blanche, Gisella; Bergh, Jacobus; Petzer, Jacobus; Castagnoli, Neal Jr (Elsevier Ltd, 2009)
    Based on a recent report that 1-methyl-3-phenylpyrrolyl analogues are moderately potent reversible inhibitors of the enzyme monoamine oxidase B (MAO-B), a series of structurally related N-methyl-2-phenylmaleimidyl analogues ...
  • Meiring, Letitia; Petzer, Jacobus Petrus; Petzer, Anél (ELSEVIER, 2013)
    In the present study, a series of 3,4-dihydro-2(1H)-quinolinone derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 3,4-dihydro-2(1H)- quinolinone derivatives ...
  • Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Strydom, Belinda (Thieme, 2012)
    Previous studies have documented that substituted 8-oxycaffeines act as inhibitors of human monoamine oxidase (MAO) B. A particularly potent inhibitor among the reported compounds was 8-(2-phenoxyethoxy)caffeine with an ...
  • Bergh, Jacobus Johannes; Mentz, Wayne; Mostert, Samantha; Petzer, Jacobus Petrus; Petzer, Anél (Elsevier, 2012)
    In a previous study we have investigated the monoamine oxidase (MAO) inhibitory properties of a series of 8-sulfanylcaffeine analogues. Among the compounds studied, 8-[(phenylethyl)sulfanyl]caffeine (IC50 = 0.223 lM) was ...
  • Strydom, Belinda; Malan, Sarel F.; Bergh, Jacobus J.; Petzer, Jacobus P.; Castagnoli, Neal (Elsevier, 2010)
    Based on recent reports that several (E)-8-styrylcaffeinyl analogues are potent reversible inhibitors of monoamine oxidase B (MAO-B), a series of 8-benzyloxycaffeinyl analogues were synthesized and evaluated as inhibitors ...
  • Bergh, Jacobus Johannes; Okaecwe, Thokozile Audrey Dorcas; Petzer, Jacobus Petrus; Swanepoel, Abraham Johannes; Petzer, Anél (Elsevier, 2012)
    A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives ...
  • Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Manley-King, Clarina Ilara (Elsevier, 2011)
    Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced ...
  • Van Der Walt, Elizna Magdalena; Bergh, Jacobus; Petzer, Jacobus; Malan, Sarel; Castagnoli, N Jr; Milczek, E M; Edmondsonb, Dale E (Elsevier Ltd, 2009)
    Previous studies have shown that (E)-8-(3-chlorostyryl)caffeine (CSC) is a specific reversible inhibitor of human monoamine oxidase B (MAO-B) and does not bind to human MAO-A. Since the small molecule isatin is a natural ...
  • Petzer, A.; Pienaar, A.; Petzer, J.P. (ELSEVIER, 2013)
    Virtual screening of a library of drugs has suggested that esomeprazole, the S-enantiomer of omeprazole, may possess binding affinities for the active sites of the monoamine oxidase (MAO) A and B enzymes. Based on this ...
  • Malan, Sarel Francois; Petzer, Jacobus Petrus; Prins, Louis Hendrik Albertus (Elsevier, 2010)
  • Prins, Louis H.A.; Petzer, Jacobus P.; Malan, Sarel F. (Elsevier, 2010)
    Monoamine oxidase (MAO) is an important drug target for the treatment of neurological disorders. A series of indole and benzofuran derivatives were synthesised and evaluated as inhibitors of the two MAO isoforms, MAO-A ...
  • Strydom, Belinda; Bergh, Jacobus J.; Petzer, Jacobus P. (ELSEVIER, 2013)
    Based on recent reports that the small molecules, isatin and phthalimide, are suitable scaffolds for the design of high potency monoamine oxidase (MAO) inhibitors, the present study examines the MAO inhibitory properties ...
  • Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Manley-King, Clarina Ilara (Elsevier, 2011)
    Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding to the MAO-B isoform ...
  • Legoabe, Lesetja Jan; Petzer, Jacobus Petrus; Kruger, Johann; Petzer, Anél; Bergh, Jacobus J. (Elsevier, 2012)
    Chromone has been reported to be a useful scaffold for the design of monoamine oxidase (MAO) inhibitors. In an attempt to discover highly potent MAO inhibitors and to contribute to the known structureeactivity relationships ...
  • Bergh, Jacobus Johannes; Malan, Sarel Francois; Petzer, Jacobus Petrus; Strydom, Belinda (Elsevier, 2010)
  • Brink, Christiaan Beyers; Elfving, Betina; Fischer, Christina; Harvey, Brian Herbert; Liebenberg, Nico; Wegener, Gregers; Müller, Heidi Kaastrup (Elsevier, 2011)
    Although it is well established that cyclic adenosine monophosphate (cAMP) signalling via cAMPdependent protein kinase (PKA)within neurons plays an important role in depression and antidepressant treatment, the importance ...

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