Browsing Faculty of Health Sciences by Title
Now showing items 529-548 of 2386
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The current development of CNS drug research
(Oxford Univ Press, 2013)In the past few years, several high profiled pharmaceutical companies have decided to shut down major research activities within the central nervous system (CNS) area. For example, in December 2011 Novartis announced ... -
Curriculum enrichment through indigenous Zulu games
(The Southern African Alliance for Sport Science, Physical Education and Recreation, 2008) -
Curriculum, curriculum development, curriculum studies? Problematising theoretical ambiguities in doctoral theses in the education field
(Education Association of South Africa, 2014)Theoretical ambiguities in curriculum studies result in conceptual mayhem. Accordingly, they hinder the development of the complicated conversation on curriculum as a verb. This article aims to contribute to reconceptualizing ... -
Cut-off values of distal forearm bone density for the diagnosis of central osteoporosis in black postmenopausal South African woman
(Health & Medical Publishing Group (JEMDSA), 2012)Background: The objective of this study was to establish a triage cut-off point or threshold for peripheral bone mineral density (BMD), applicable to black postmenopausal women, and that could be used as a screening method ... -
Cutaneous tuberculosis overview and current treatment regimens
(Elsevier, 2015)Tuberculosis is one of the oldest diseases known to humankind and it is currently a worldwide threat with 8e9 million new active disease being reported every year. Among patients with co-infection of the human immunodeficiency ... -
CVD risk factors are related to plasma fibrin clot properties independent of total and or γ’ fibrinogen concentration
(Elsevier, 2014)Introduction: Cardiovascular disease (CVD) risk factors are associated with total fibrinogen concentration and/or altered clot structure. It is however, unclear whether such associations with clot structure are ascribed ... -
CYP2B6 haplotype predicts efavirenz plasma concentration in black South African HIV-1-infected children: a longitudinal pediatric pharmacogenomic study
(Mary Ann Liebert, 2017)South Africa has the highest burden of the human immunodeficiency virus (HIV) infection globally. Efavirenz (EFV), a frequently used drug against HIV infection, displays a relationship between drug concentration and ... -
D-dimer relates positively with increased blood pressure in black South Africans: the SABPA study
(Elsevier, 2014)Introduction Hypertension is highly prevalent in black South Africans in which morbidity and mortality from stroke are on the increase. Elevated blood pressure and haemostatic markers can induce changes in blood rheology ... -
A decade of nutrition research in Africa: assessment of the evidence base and academic collaboration
(Cambridge University Press, 2015)Objective: Malnutrition in Africa has not improved compared with other regions in the world. Investment in the build–up of a strong African research workforce is essential to provide contextual solutions to the nutritional ... -
Decolonisation of the Nursing Curriculum by the South African Nursing Students' Association
(UNISA Press, 2019)The South African Nursing Students’ Association (SANSA) held its fourth annual symposium which was co-hosted by the Tshwane University of Technology (TUT) and the University of Pretoria (UP) on 4 to 6 July 2018 -
Decolonising social work research with families experiencing intergenerational trauma
(UNISA Press, 2018)This article focuses on social work research with displaced families in the Western Cape, South Africa, who have experienced both the historical trauma of their slave past and the trauma of displacement during apartheid. ... -
Decreased in vivo α2 adrenoceptor binding in the Flinders Sensitive Line rat model of depression
(Elsevier, 2015)Depression is a debilitating heterogenous disorder and the underlying mechanisms remain elusive. Alterations in monoaminergic neurotransmission, including noradrenergic, have been implicated in the etiology of depression. ... -
The Deep Genome Project
(BMC, 2020)In vivo research is critical to the functional dissection of multi-organ systems and whole organism physiology, and the laboratory mouse remains a quintessential animal model for studying mammalian, especially human, ... -
Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort: the SABPA study
(Wiley, 2017)Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative ... -
Defensive coping and renovascular disease risk. Adrenal fatigue in a cohort of Africans and Caucasians: the SABPA study
(Elsevier, 2015)Background: Defensive coping is an established cardiovascular risk factor in Africans. Additionally, chronic, excessive or inadequate hypothalamic pituitary adrenal axis (HPAA) stress responses could either increase or ... -
Defensive coping and subclinical vascular disease risk – associations with autonomic exhaustion in Africans and caucasians: the SABPA study
(Elsevier, 2012)Objective The defensive active coping response is a recognised cardiovascular risk factor in Africans, especially in men. It is uncertain whether autonomic dysfunction might be the underlying cause. We therefore investigated ... -
Defensive coping facilitated a smaller cortisol-to-estradiol ratio and a higher hypertension risk: the SABPA study
(Taylor & Francis, 2018)Objectives: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It ... -
Defensive coping facilitates higher blood pressure and early sub–clinical structural vascular disease via alterations in heart rate variability: the SABPA study
(Elsevier, 2013)Objectives: Defensive coping (AC) responses in urban African males have been associated with vascular responsiveness, partly explaining autonomic nervous system dysfunction. We therefore aimed to assess whether AC responses ... -
Defensive coping, urbanization, and neuroendocrine function in Black Africans: the THUSA study
(Wiley, 2012)Dissociation between b-adrenergic behavioral and physiological defensive active coping (AC) responses was associated with cardiometabolic risk in urban but not rural African males. Whether this is partly driven by underlying ... -
Degree of obesity influences the relationship of PAI-1 with body fat distribution and metabolic variables in African women
(Elsevier, 2016)Introduction Although the relationship of plasminogen activator inhibitor-1 (PAI-1) with obesity has been well established, the relationship of PAI-1 with different body fat distribution patterns is less clear particularly ...