Browsing Faculty of Health Sciences by Title
Now showing items 540-559 of 2377
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Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort: the SABPA study
(Wiley, 2017)Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative ... -
Defensive coping and renovascular disease risk. Adrenal fatigue in a cohort of Africans and Caucasians: the SABPA study
(Elsevier, 2015)Background: Defensive coping is an established cardiovascular risk factor in Africans. Additionally, chronic, excessive or inadequate hypothalamic pituitary adrenal axis (HPAA) stress responses could either increase or ... -
Defensive coping and subclinical vascular disease risk – associations with autonomic exhaustion in Africans and caucasians: the SABPA study
(Elsevier, 2012)Objective The defensive active coping response is a recognised cardiovascular risk factor in Africans, especially in men. It is uncertain whether autonomic dysfunction might be the underlying cause. We therefore investigated ... -
Defensive coping facilitated a smaller cortisol-to-estradiol ratio and a higher hypertension risk: the SABPA study
(Taylor & Francis, 2018)Objectives: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It ... -
Defensive coping facilitates higher blood pressure and early sub–clinical structural vascular disease via alterations in heart rate variability: the SABPA study
(Elsevier, 2013)Objectives: Defensive coping (AC) responses in urban African males have been associated with vascular responsiveness, partly explaining autonomic nervous system dysfunction. We therefore aimed to assess whether AC responses ... -
Defensive coping, urbanization, and neuroendocrine function in Black Africans: the THUSA study
(Wiley, 2012)Dissociation between b-adrenergic behavioral and physiological defensive active coping (AC) responses was associated with cardiometabolic risk in urban but not rural African males. Whether this is partly driven by underlying ... -
Degree of obesity influences the relationship of PAI-1 with body fat distribution and metabolic variables in African women
(Elsevier, 2016)Introduction Although the relationship of plasminogen activator inhibitor-1 (PAI-1) with obesity has been well established, the relationship of PAI-1 with different body fat distribution patterns is less clear particularly ... -
Dependence of cardiac systolic function on elevated fatty acid availability in obese, insulin-resistant rats
(Elsevier, 2016)Background Clinical data advocating an adverse effect of obesity on left ventricular (LV) systolic function independent of comorbidities is controversial. We hypothesized that in obesity with prediabetic insulin resistance, ... -
Depression symptoms facilitated fibrinolytic dysregulation and future coronary artery disease risk in a black male cohort: the sympathetic activity and ambulatory blood pressure in Africans study
(Wolters Kluwer, 2017)Background: Hypercoagulation is associated with coronary artery disease (CAD). Whether depression symptoms dysregulate inflammatory and hemostatic markers in an African cohort is not known; therefore, we assessed the ... -
Depression, cardiometabolic function and left ventricular hypertrophy in African men and women: the SABPA study
(Taylor & Francis, 2013)Depressive symptoms are associated with an increased risk for developing cardiovascular diseases, driven by its link to the metabolic syndrome (MetS). This phenomenon, however, still needs to be investigated in the African ... -
Depressive symptoms and 24-hour ambulatory blood pressure in Africans: the SABPA study
(Hindawi, 2012)Disturbances in circadian rhythm might play a central role in the neurobiology of depression. We examined the association between depressive symptoms and 24-hour ambulatory BP in a sample of 405 (197 black and 208 Caucasian) ... -
Depressive symptoms and sub-clinical atherosclerosis in Africans: role of metabolic syndrome, inflammation and sympathoadrenal function
(Elsevier, 2011)Depressive symptoms have been consistently associated with sub-clinical atherosclerosis and future risk of coronary heart disease events. However, the pathways linking depression and coronary atherosclerosis are poorly ... -
Deriving an optimal threshold of waist circumference for detecting cardiometabolic risk in sub-Saharan Africa
(Nature, 2018)BACKGROUND: Waist circumference (WC) thresholds derived from western populations continue to be used in sub-Saharan Africa (SSA) despite increasing evidence of ethnic variation in the association between adiposity and ... -
Dermal exposure and changes in skin barrier function of base metal refinery workers co-exposed to cobalt and nickel
(The South African Society of Occupational Medicin, 2013)Refi nery workers are exposed to many metals, including cobalt and nickel, both of which are skin sensitisers, causing allergic contact dermatitis. Dermal exposure, and changes in skin barrier function [skin hydration, ... -
Dermal exposure sampling methods: an overview
(South African Society of Occupational Medicine, 2008) -
Describing a design thinking methodology to develop sustainable physical activity and nutrition interventions in low resourced settings
(Springer, 2018)The objective of the study is to describe how design thinking as a participatory process can be applied in determining how sustainable physical activity and nutrition interventions should be implemented in a low resourced ... -
Descriptive sensory analysis and consumer acceptability of lucerne (Medicago sativa L.)
(Emerald Group Publishing Limited, 2015)Abstract : "Purpose A lack of available literature exists about sensory data on lucerne (which is mainly used for animal feed) as an underutilised protein source for human consumption in South Africa (SA). Developing ... -
The design and evaluation of a hope enhancement programme for adults
(Taylor & Francis, 2008)The study evaluated the effectiveness of a hope enhancement programme for a group of adults and its impact on general psychological well-being. The intervention programme focused on participants' abilities to set feasible ... -
The design and evaluation of an l-dopa-lazabemide prodrug for the treatment of Parkinson’s disease
(MDPI, 2017)l-Dopa, the metabolic precursor of dopamine, is the treatment of choice for the symptomatic relief of the advanced stages of Parkinson’s disease. The oral bioavailability of l-dopa, however, is only about 10% to 30%, and ... -
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents
(Elsevier, 2018)New 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives are proposed as dual-target-directed monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE) inhibitors, as well as antioxidant agents, for the treatment of ...