Browsing Faculty of Health Sciences by Title
Now showing items 560-579 of 2385
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Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents
(Elsevier, 2018)New 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives are proposed as dual-target-directed monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE) inhibitors, as well as antioxidant agents, for the treatment of ... -
Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates
(RSC, 2016)The design, synthesis and biological evaluation of a series of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4- diamines is described. These compounds exhibited in vitro antiplasmodial activity in the low nanomolar range against ... -
Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase
(Springer, 2020)The most effective treatment of Parkinson’s disease is restoring central dopamine levels with levodopa, the metabolic precursor of dopamine. However, due to extensive peripheral metabolism by aromatic L-amino acid decarboxylase ... -
Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives
(Wiley, 2019)Tuberculosis is the deadliest infectious disease affecting humankind with a death toll of approximately 1.7 million people in 2016. The increasing prevalence of multidrug‐resistant strains of the causative pathogen, ... -
Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles
(MDPI, 2019)New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B. The most important chiral ... -
A desire for weight loss in season increases disordered eating behaviour risk and energy deficiency in athletes
(MedPharm Publications, 2014)Objective: The objective was to explore eating behaviour, body image and energy status in female university team sport athletes. Design: This was a cross-sectional, descriptive study design. Setting: The setting was ... -
Determinants of childhood diarrhea among under-five year old children in Nigeria: a population-based study using the 2013 demographic and health survey data
(Turkish National Pediatric Society, 2018)The study aims to identify socioeconomic, demographic, environmental and child baseline factors associated with Childhood Diarrhea (CD) among under-five year old children in Nigeria. We utilized cross-sectional data from ... -
Determinants of plasma fibrin clot lysis measured using three different assays in healthy subject
(Elsevier, 2021)Introduction Several methods for measuring fibrinolytic capacity in plasma have been developed yielding frequently inconsistent results. We investigated which factors determine fibrinolytic capacity in three plasma-based ... -
Determinants of pre-lacteal feeding practices in urban and rural Nigeria; a population-based cross-sectional study using the 2013 Nigeria demographic and health survey data
(AJOL, 2017)Background: Prelacteal feeding (PLF) is a barrier to exclusive breast feeding. Objective: To determine factors associated with PLF in rural and urban Nigeria. Methods: We utilized data from the 2013 Nigerian Demographic ... -
Determinants of undernutrition prevalence in children aged 0–59 months in sub-Saharan Africa between 2000 and 2015. A report from the World Bank database
(Cambridge Univ Press, 2019)Objective To determine undernutrition prevalence in 0–59-month-old children and its determinants during the period 2000–2015 in sub-Saharan Africa. Design Ecological study of time series prevalence of undernutrition ... -
Determination of lovastatin, mevastatin, rosuvastatin and simvastatin with HPLC by means of gradient elution
(Avoxa, 2019)A novel HPLC method with UV detection was developed and validated in skin penetration (in vitro) studies to identify and quantify lovastatin, mevastatin, rosuvastatin and simvastatin. A Venusil XBP C18 (2), 150 x 4.6 mm, ... -
Determination of salivary efavirenz by liquid chromatography coupled with tandem mass spectrometry
(Elsevier, 2010)A novel and robust screening method for the determination of the non-nucleoside reverse transcriptase inhibitor, efavirenz (EFV), in human saliva has been developed and validated based on high performance liquid chromatography ... -
Determination of the therapeutic efficacy of a novel Pheroid® formulation in a rodent tuberculosis model
(Elsevier, 2019)Resistance against the current TB treatment regimens is spreading. A combination of the current TB regime with a novel drug delivery system, might lead to reduced resistance, shorter treatment durations and increased ... -
Determining cut-off values for neck circumference as a measure of the metabolic syndrome amongst a South African cohort: the SABPA study
(Springer-Science, 2012)The aim was to determine receiver operating characteristic (ROC) neck circumference (NC) cut offs best associated with the metabolic syndrome (MetS) in a South African cohort. We included 409 urban Africans and Caucasians ... -
Determining ethnic-, gender-, and age-specific waist circumference cut-off points to predict metabolic syndrome: the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study
(MedPharm Publications (Medical and Pharmaceutical Publications), 2013)Objective: The aim was to determine receiver-operating characteristic (ROC) waist circumference (WC) cut-off points best associated with metabolic syndrome (MetS) in a cohort of South African teachers. Design: Target ... -
Determining potential drug-drug interactions between lopinavir/ritonavir and other antiretrovirals and prescribed daily doses in a section of the private health care sector in South Africa
(Academic Journals, 2013)Lopinavir/ritonavir forms part of the antiretroviral therapy for the treatment of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). The aim of this non-experimental, quantitative drug-utilization ... -
Determining sample size adequacy for animal model studies in nutrition research: limits and ethical challenges of ordinary power calculation procedures
(Taylor & Francis, 2020)Animal models are widely used in the field of nutrition research. Scientifically and ethically sound experiments need an adequate number of experimental units. The use of 5-10 units is common, but such sample sizes can be ... -
Determining the impact of hunting trips on the hunter s quality of life
([AJHTL], 2015)The objective of this study was to investigate the impact of a hunting trip on hunters‟ quality of life (QoL) as measured by life domains. A number of life domains that are directly related to a hunting trip may affect the ... -
Determining the waist circumference cut off which best predicts the metabolic syndrome components in urban Africans: the SABPA study
(Thieme Publications, 2011)Various studies have shown that the relationship between waist circumference (WC) and abdominal obesity is age, gender as well as ethnicity-dependent. WC criteria for Sub Saharan Africans have not been defined by the ... -
Determining the worldwide prevalence of obesity
(Elsevier, 2018)The NCD Risk Factor Collaboration study (Dec 16, 2017, p 2627) 1 is a landmark description of the progress of the obesity pandemic, but substantially underestimates the scale ...