Browsing Faculty of Health Sciences by Title
Now showing items 702-721 of 2377
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Dopaminergic and serotonergic modulation of social reward appraisal in zebrafish (Danio rerio) under circumstances of motivational conflict: towards a screening test for anti-compulsive drug action
(Elsevier, 2020)Cognitive flexibility, shown to be impaired in patients presenting with compulsions, is dependent on balanced dopaminergic and serotonergic interaction. Towards the development of a zebrafish (Danio rerio) screening test ... -
Double product and end-organ damage in African and Caucasian men: the SABPA study
(ELSEVIER, 2013)Background: Increasing urbanisation in sub-Saharan African countries is causing a rapid increase in cardiovascular disease. Evidence suggests that Africans have higher blood pressures and a higher prevalence of hyperte ... -
Double product reflects the predictive power of systolic pressure in the general population: evidence from 9,937 participants
(Oxford University Press, 2013)BACKGROUND The double product (DP), consisting of the systolic blood pressure (SBP) multiplied by the pulse rate (PR), is an index of myocardial oxygen consumption, but its prognostic value in the general population remains ... -
Drink lots of clean, safe water: a food–based dietary guideline for South Africa
(MedPharm Publications, 2013)The purpose of this review is to summarise the literature that supports the importance of the food-based dietary guideline on water consumption. General recommendations for total daily water intake are between 2 and 3.7 ... -
Drink types unmask the health risks associated with alcohol intake: prospective evidence from the general population
(Elsevier, 2020)Background & aims Uncertainty still exists on the impact of low to moderate consumption of different drink types on population health. We therefore investigated the associations of different drink types in the form of ... -
Drug bioavailability enhancing agents of natural origin (bioenhancers) that modulate drug membrane permeation and pre-systemic metabolism
(MDPI, 2019)Many new chemical entities are discovered with high therapeutic potential, however, many of these compounds exhibit unfavorable pharmacokinetic properties due to poor solubility and/or poor membrane permeation characteristics. ... -
Drug safety Africa: an overview of safety pharmacology & toxicology in South Africa
(Elsevier, 2019)This meeting report is based on presentations given at the first Drug Safety Africa Meeting in Potchefstroom, South Africa from November 20–22, 2018 at the North-West University campus. There were 134 attendees (including ... -
Drug use among youth and adults in a population-based survey in South Africa
(AOSIS, 2018)Objective: Illicit drug use is a growing public health problem. The aim of the study was to assess the prevalence of drug use and the sociodemographic and health characteristics that influence it among young and adult South ... -
Dual inhibition of monoamine oxidase B and antagonism of the adenosine A2A receptor by (E,E)-8-(4phenylbytadien-1-yl) caffeine analogues
(Elsevier, 2008)The adenosine A2A receptor has emerged as an attractive target for the treatment of Parkinson’s disease (PD). Evidence suggests that antagonists of the A2A receptor (A2A antagonists) may be neuroprotective and may help to ... -
A dual inhibitor of FAAH and TRPV1 channels shows dose-dependent effect on depression-like behaviour in rats
(Cambridge Univ Press, 2017)Objective: The cannabinoid receptor 1 (CB1) and transient receptor potential cation channel subfamily V member 1 (TRPV1) are proposed to mediate opposite behavioural responses. Their common denominator is the endocannabinoid ... -
Dual radiolabeling as a technique to track nanocarriers: the case of gold nanoparticles
(MDPI, 2015)Gold nanoparticles (AuNPs) have shown great potential for use in nanomedicine and nanotechnologies due to their ease of synthesis and functionalization. However, their apparent biocompatibility and biodistribution is still ... -
Dual-target-directed drugs that block monoamine oxidase B and adenosine A2A receptors for Parkinson’s disease
(Springer, 2009)Inadequacies of the current pharmacotherapies to treat Parkinson’s disease (PD) have prompted efforts to identify novel drug targets. The adenosine A2A receptor is one such target. Antagonists of this receptor (A2A ... -
Early detection of cardiovascular risk in children: is there an alternative beyond routine blood pressure measurement?
(American Heart Association, 2019) -
Early substance use initiation and psychological distress among adolescents in five ASEAN countries: a cross-sectional study
(Dove Press, 2019)Aim: The study aimed to assess the associations between substance use early initiation (<12 years) (smoking cigarettes, alcohol and drug use) with psychological distress among adolescents in five ASEAN countries. Methods: ... -
Early Vascular Aging (EVA): new directions in cardiovascular protection. Preface
(Elsevier, 2015)Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The ... -
Early vascular aging in the HIV infected: is arterial stiffness assessment the ideal tool?
(Taylor & Francis, 2017) -
Eat dry beans, split peas, lentils and soya regularly: a food–based dietary guideline
(MedPharm Publications, 2013)The objective of this paper is to review recent scientific evidence to support the food-based dietary guideline (FBDG): “Eat dry beans, split peas, lentils and soya regularly”. In this review, legumes are synonymous with ... -
Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: a HESI-sponsored cross-company evaluation
(Elsevier, 2020)Introduction Alterations in cardiac contractility can have significant clinical implications, highlighting the need for early detection of potential liabilities. Pre-clinical methods to assess contractility are typically ... -
The ECO-MACH framework and protocol for managing children with mental health issues in alternative care facilities
(SAPSAC, 2017)A child that is mentally healthy develops psychologically, emotionally, creatively, intellectually and spiritually (Dwivedi & Harper, 2004). Implicit in the successful development of children is their mental health. The ... -
Educating and training a workforce for nutrition in a post–2015 world
(American Society for Nutrition, 2015)Nearly all countries in the world today are burdened with malnutrition, manifesting as undernutrition, micronutrient deficiencies, and/or overweight and obesity. Despite some progress, efforts to alleviate malnutrition are ...