Browsing Faculty of Health Sciences by Title
Now showing items 779-798 of 2385
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Effects of oral administration of synthesized d-amides of eflornithine in the rat
(Thieme, 2010)The purpose of this study was to synthesize a series of δ-amide derivatives of the antitrypanosomal drug eflornithine (2,5-diamino-2-(difluoromethyl)pentanoic acid hydrochloride, DMFO, CAS 70052-12-9), to determine their ... -
Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration
(Elsevier, 2012)The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study ... -
The effects of rehabilitation on intellectually-disabled people - a systematic review
(AOSIS, 2014)Background: Rehabilitation has emerged as a comprehensive approach to addressing intellectually-disabled peoples’ skill deficits, improving competencies and facilitating optimal functioning in order to ... -
Effects of strength and endurance exercise order on endocrine responses to concurrent training
(Taylor & Francis, 2017)The present study examined the effect of strength and endurance training order on the endocrine milieu associated with strength development and performance during concurrent training. A randomised, between-groups design ... -
The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical n-methyl-d-aspartate and d1 receptor binding in rats
(Elsevier, 2010)Glutamate and dopamine disturbances are implicated in frontal cortical dysfunction in schizophrenia. Little, however, is known about the nature of dopamine D1 and N-methyl-d-aspartate (NMDA) receptor interactions in the ... -
Effects of the cosurfactant 1-butanol and feed composition on nanoparticle properties
(Wiley, 2008)The concentration of the cosurfactant 1-butanol (BuOH) determined the polymer weight and size for a series of poly(styrene-co-methyl methacrylate)s (P(St-co-MMA)) synthesized by the free-radical (o/w) microemulsion technique. ... -
Effects of wheat-flour biscuits fortified with iron and EDTA, alone and in combination, on blood lead concentration, iron status, and cognition in children: a double-blind randomized controlled trial
(ASN, 2016)Background: Lead is a common neurotoxicant and its absorption may be increased in iron deficiency (ID). Thus, iron fortification to prevent ID in populations is a promising lead mitigation strategy. Two common fortificants ... -
Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial
(ABP - Brazilian Psychiatric Association, 2019)Objective: Bipolar depression is characterized by neurobiological features including perturbed oxidative biology, reduction in antioxidant levels, and a concomitant rise in oxidative stress markers. Bipolar depression ... -
Efficacy of different treatment methods for ADHD and associated neuromotor coordination difficulties
(LAM Publications, 2017)This study investigated the efficacy of different treatment methods for Attention Deficit Hyperactivity Disorder (ADHD) in improving attention, and neuromotor difficulties. Children (N=95, 60 boys; 35 girls) with a mean ... -
Efficacy of home-based kinesthesia, balance & agility exercise training among persons with symptomatic knee osteoarthritis
(University of Uludag, 2012)The purpose of this study was to determine the efficacy of a home-based kinesthesia, balance and agility (KBA) exercise program to improve symptoms among persons age ≥ 50 years with knee osteoarthritis (OA). Forty-four ... -
Efficacy of novel small-quantity lipid-based nutrient supplements in improving long-chain polyunsaturated fatty acid status of South African infants: a randomised controlled trial
(Springer, 2020)Background/objectives The objective of this study was to investigate the efficacy of small-quantity lipid-based nutrient supplements (SQ-LNS) containing essential fatty acids (EFAs) with or without long-chain polyunsaturated ... -
Efflux as a mechanism of antimicrobial drug resistance in clinical relevant microorganisms: the role of efflux inhibitors
(Taylor & Francis, 2017)Introduction: Microbial resistance against antibiotics is a serious threat to the effective treatment of infectious diseases. Several mechanisms exist through which microorganisms can develop resistance against antimicrobial ... -
An elderly, urban population: their experiences and expectations of pharmaceutical services in community pharmacies
(AOSIS, 2017)Objective: The aim of this study was to determine the pharmaceutical services experiences of an elderly, urban population in relation to their expectations in community pharmacy. Design: and setting: The study was a ... -
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
(Elsevier, 2012)Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment ... -
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
(Elsevier, 2012)Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment ... -
Electroconvulsive shocks decrease α2-adrenoceptor binding in the Flinders rat model of depression
(Elsevier, 2015)Despite years of drug development, electroconvulsive therapy (ECT) remains the most effective treatment for severe depression. The exact therapeutic mechanism of action of ECT is still unresolved and therefore we tested ... -
Elevated estimated arterial age is associated with metabolic syndrome and low-grade inflammation
(Wolters Kluwer, 2016)Background: Arterial age can be estimated from equations relating arterial stiffness to age and blood pressure in large cohorts. We investigated whether estimated arterial age (eAA) was elevated in patients with the metabolic ... -
Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression
(Springer Nature, 2016)Elevation of the proinflammatory cytokine IL-6 has been implicated in depression; however, the mechanisms remain elusive. MicroRNAs (miRNAs) are small non-coding RNAs that inhibit gene expression post-transcriptionally. ... -
Elimination of host and dead pathogenic organism DNA for improved diagnostic outcome
(Elsevier, 2019)Molecular-based diagnostic techniques used to detect bacterial infections in clinical samples are often unable to discriminate between living and dead bacteria and extracellular DNA. This presents a major problem, leading ... -
Elimination of Schistosoma mansoni in infected mice by slow release of artemisone
(Elsevier, 2017)The current treatment of schistosomiasis is based on the anti-helminthic drug praziquantel (PZQ). PZQ affects only the adult stages of schistosomes. In addition, resistance to PZQ is emerging. We suggest a drug, which ...