Browsing Faculty of Health Sciences by Title
Now showing items 1826-1845 of 2377
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QTc prolongation, increased NT-proBNP and pre-clinical myocardial wall remodeling in excessive alcohol consumers: the SABPA study
(Elsevier, 2018)Alcohol contributes greatly to vascular and structural modifications. Due to differences in the metabolism and tolerance of alcohol between ethnic groups, the manner of these modifications may differ. We investigated the ... -
Qualitative job insecurity and turnover intention: the mediating role of basic psychological needs in public and private sectors
(Emerald, 2018)Purpose The purpose of this paper is to test two hypotheses. First, an indirect relationship between qualitative job insecurity and turnover intention through basic psychological need satisfaction was investigated. Second, ... -
The qualitative research proposal
(Democratic Nursing Organisation of South Africa (DENOSA), 2008) -
Quality of life, physical activity and cardiorespiratory fitness in black African women: B-Healthy project
(Springer, 2020)Purpose To study the associations between physical activity (PA), cardiorespiratory fitness (CRF), and health-related quality of life (HRQoL) in black African women from a low socioeconomic community in South Africa. ... -
Quantification of systemic renin-angiotensin system peptides of hypertensive black and white African men established from the RAS-Fingerprint
(Sage, 2016)Objective: The objective of this study was to make use of a quantitative and qualitative approach comparing the systemic renin-angiotensin system (RAS) of hypertensive black and white African men by using RAS equilibrium ... -
Quantitative determination of octadecenedioic acid in human skin and transdermal perfusates by gas chromatography-mass spectrometry.
(Oxford Univ Press, 2008)A gas chromatographic (GC) method with mass spectrometric (MS) detection is developed and validated for the accurate and precise determination of octadecenedioic acid (C18:1 DIOIC) in human skin samples and transdermal ... -
Quantitative hippocampal structural changes following elctroconvulsive seizure treatment in a rat model of depression
(Wiley, 2012)Objective: The pathophysiology of depression and the effects of antidepressant treatment are hypothesized to be related to hippocampal structural changes. This study aims to investigate the effect of electroconvulsive ... -
A quick and painless reminder: the pharmacotherapy of rheumatoid arthritis in primary practice
(Taylor & Francis, 2018)Rheumatoid arthritis, an auto-immune disorder, is characterised by chronic inflammation of the joints, synovial hyperplasia and bone erosion. These pathological features are promoted by a synovial microenvironment featuring ... -
Quinolone-isoniazid hybrids: synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation
(RSC, 2019)Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached via a hydrazide–hydrazone bond were synthesised and ... -
Radiopharmaceutical enhancement by drug delivery systems: a review
(Elsevier, 2018)Introduction Drug delivery systems are entities designed to alter the biological behaviour of the pharmaceutical active ingredients that they carry in order to afford more beneficial biodistribution and safety profiles. ... -
Randomised controlled feasibility trial of a web-based weight management intervention with nurse support for obese patients in primary care
(BioMed Central, 2014)Background: There is a need for cost-effective weight management interventions that primary care can deliver to reduce the morbidity caused by obesity. Automated web-based interventions might provide a solution, but ... -
A randomized, controlled trial of omega-3 fatty acids plus an antioxidant for relapse prevention after antipsychotic discontinuation in first-episode schizophrenia
(Elsevier, 2014)Background: While antipsychotics are effective in the maintenance treatment of schizophrenia they have safety and tolerability risks. We investigated whether a combination of omega-3 polyunsaturated fatty acids (ω−3 ... -
Rapid antidepressant effect of ketamine correlates with astroglial plasticity in the hippocampus
(Wiley, 2017)Background and purpose Astroglia contribute to the pathophysiology of major depression and antidepressant drugs act by modulating synaptic plasticity; therefore, the present study investigated whether the fast antidepressant ... -
Rapid cell lysis and DNA capture in a lysis microreactor
(Elsevier, 2012)In clinical diagnostics, the detection and identification of bacterial organisms based on the analysis of their nucleic acids require cell lysis and DNA extraction from clinical samples. A lysis microreactor (LMR) has been ... -
Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner
(Elsevier, 2020)The prevalence of major depressive disorder (MDD) is higher in women than men. Importantly, a differential behavioral response by sex to the antidepressant response to ketamine in rodents has been reported. Mechanistically, ... -
Rapid thermal cycling of three phase change materials (PCMs) for cooking applications
(Springer, 2018)The suitability of the use of acetanilide, meso-erythritol and In-48Sn as phase change materials (PCMs) in latent heat thermal storage systems (LHTES) for cooking applications has been investigated under high charging and ... -
Rasch analysis of the Meaning in life Questionnaire among adults from South Africa, Australia, and New Zealand
(BioMed Central, 2016)Background: Meaning in life is a key indicator of subjective well-being and quality of life. Further developments in understanding and enhancing the construct will depend inter alia on the sound measurement thereof. This ... -
Rasch analysis of the Satisfaction with Life Scale across countries: findings from South Africa and Italy
(Springer, 2019)The Satisfaction with Life Scale (SWLS) is widely used to assess global satisfaction with life. Although the scale’s psychometric properties were extensively investigated through different methods, Rasch analysis can provide ... -
The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine
(Elsevier, 2020)We have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and Brain Derived Neurotrophic Factor (BDNF)-associated ... -
(Re)creating community: experiences of older women forcibly relocated during apartheid
(Wiley, 2014)This article explores sense of community with a group of older African women, who were forcibly relocated during apartheid. The situation of a marginalised group, with a history of disconnection from younger generations ...